Gender inequalities in prescribing and initiation patterns of guideline-recommended drugs after acute myocardial infarction.

Background: European guidelines recommend the prescription of certain drugs after acute myocardial infarction (AMI). The existence of gender differences in pharmacological treatment after an AMI has been described. This study aims to describe and analyse, using real-world data (RWD), whether there are gender differences in the prescribing patterns and initiation of treatment in secondary prevention after a first AMI, and which are the factors that explain these differences.

Primary care utilisation in different patients' profiles with cardiovascular risk factors.

Background: This study aimed to identify profiles of patients with cardiovascular disease (CVD) risk factors, based on their sociodemographic and clinical characteristics, and to analyse how their complexity is related to their frequency of visits in Primary Care.

Methods: Observational longitudinal study conducted in the Spanish CArdiovascular Risk factors for HEalth Services research (CARhES) cohort. Individuals older than 15 with hypertension, type 2 diabetes mellitus (DM) and/or dyslipidaemia in 2017 were selected and followed until 2021.

Norms for the EQ-5D-5L among the general adult population in Alberta, Canada.

Purpose: To present EQ-5D-5L population norms for the general adult population in Alberta, Canada.

Methods: We analyzed data from 11 population-based surveys conducted in Alberta between 2012 and 2021. By applying appropriate sampling weights, we estimated normative data for the EQ-5D-5L dimensions, index scores, and visual analogue scale (VAS) scores.

Visible Light-Induced Regioselective to Isomerization of Polarized 1,3-Dienes: Experimental and Theoretical Insights.

The stereocontrol of → isomerization on a (1,3)-diene, instead of a simple alkene, can be more challenging due to the increased number of isomerization possibilities. Herein, we report visible light-mediated regioselective (1,3 → 1,3) isomerization of (1,3)-diene. The reaction conditions are mild and easy to apply and can be applied to a wide range of substances, with an excellent yield and selectivity (90:10).

External photocatalyst-free photocycloaddition between triplet vinylnitrenes with 1,3-biradical character and activated olefins under 420 nm LEDs.

Herein, we report that triplet vinylnitrenes with 1,3-biradical character can directly participate in photocycloaddition reactions with olefins to produce single diastereomers of the corresponding 1-pyrrolines under 420 nm LEDs in acetonitrile solvent. Moreover, a one-pot method has been developed to produce pyrroles directly through photocycloaddition and oxidation sequences. The excited state of the substrate olefin can sensitize vinyl azide energy transfer, eliminating the need for an external photocatalyst or sensitizer.