Publications by authors named "S Malatesta"
Background: Adverse drug reactions (ADRs) to tuberculosis (TB) medications make treatment completion challenging. We investigated the impact of alcohol, human immunodeficiency virus (HIV), and other patient determinants on ADRs and treatment adherence.
Methods: We administered monthly ADR questionnaires to participants with TB in Worcester, South Africa.
Background: Metabolic syndrome represents a pancreatic ductal adenocarcinoma (PDAC) risk factor. Metabolic alterations favor PDAC onset, which occurs early upon dysmetabolism. Pancreatic neoplastic lesions evolve within a dense desmoplastic stroma, consisting in abundant extracellular matrix settled by cancer associated fibroblasts (CAFs).
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- The COVID-19 pandemic significantly disrupted tuberculosis (TB) treatment, particularly impacting directly observed therapy (DOT) adherence programs in South Africa.
- Data from a study comparing DOT adherence rates before (pre-COVID-19) and after (post-COVID-19 lockdown) revealed marked increases in non-adherence rates, with the highest non-adherence observed immediately after the first lockdown.
- The findings suggest that the negative impact on DOT adherence persisted post-lockdown, highlighting the need for further investigation into the barriers that worsened treatment adherence during and after the pandemic.
Background: In South Africa, an estimated 11% of the population have high alcohol use, a major risk factor for TB. Alcohol and other substance use are also associated with poor treatment response, with a potential mechanism being altered TB drug pharmacokinetics.
Objectives: To investigate the impact of alcohol and illicit substance use on the pharmacokinetics of first-line TB drugs in participants with pulmonary TB.
Hereditary breast and ovarian cancer (HBOC) syndrome is responsible for approximately 10% of breast cancers (BCs). The HBOC gene panel includes both high-risk genes, i.e.
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