Publications by authors named "S Makela"

The study of the cortical basis of reading has greatly benefited from the use of naturalistic paradigms that permit eye movements. However, due to the short stimulus lengths used in most naturalistic reading studies, it remains unclear how reading of texts comprising more than isolated sentences modulates cortical processing. To address this question, we used magnetoencephalography to study the spatiospectral distribution of oscillatory activity during naturalistic reading of multi-page texts.

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Old World Orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS) characterized by increased vascular permeability and acute kidney injury (AKI). Despite the systemic nature of the disease, the virus enters humans through inhalation and therefore initially encounters the immunoglobulin class A (IgA) dominated mucosal immune system. Herein, we characterized systemic IgA responses and their potential relationship to the mucosal immune activation by examining blood samples obtained from patients hospitalized due to acute Puumala orthohantavirus infection.

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Background: Pervasive technologies are used to investigate various phenomena outside the laboratory setting, providing valuable insights into real-world human behavior and interaction with the environment. However, conducting longitudinal field trials in natural settings remains challenging due to factors such as low recruitment success and high dropout rates due to participation burden or data quality issues with wireless sensing in changing environments.

Objective: This study gathers insights and lessons from 3 real-world longitudinal field studies assessing human behavior and derives factors that impacted their research success.

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The articles in this Special Issue, "Hantavirus Research in Finland", were published between 2021 and 2022 [...

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Article Synopsis
  • 1L immunotherapy has shown better overall survival rates in metastatic melanoma compared to 1L targeted therapy, especially for eligible patients.
  • A study in Finland (2014-2021) compared outcomes of patients treated with 1L immunotherapy vs. 1L targeted therapy, highlighting significant differences in survival rates and baseline characteristics.
  • Patients receiving 1L immunotherapy had fewer severe baseline conditions and higher 2-year survival rates (60.3-63.5%) compared to those on 1L targeted therapy (33.8%).
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