Tetracarpidium conophorum nuts (African walnuts) up-regulated adiponectin and PPAR-γ expressions with reciprocal suppression of TNF-α gene in obesity.

Tetracarpidium conophorum nuts are nutrient-dense Nigerian snacks associated with weight regulation. This study explores the nuts' impact on adipose tissue gene expression associated with low-grade inflammation. Ethanol whole extract (EWE), ethyl-acetate fraction (EAF) and the resulting residue (RES) were orally administered once daily to MSG-induced obese rats for 6 weeks (n = 6).

Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs.

This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading.

Extracorporeal Membrane Oxygenation in the Management of Takotsubo Cardiomyopathy Secondary to Mitral Valve Replacement Surgery: A Case Report.

Unlike classical myocardial infarction, acute emotional or physical stress can trigger distinct but transient wall motion abnormalities with patent coronary arteries. Takotsubo cardiomyopathy (TC) classically presents as systolic and diastolic left ventricular (LV) dysfunction, which is widely accepted to be secondary to catecholamine-induced microvascular dysfunction. Our case report describes a 26-year-old female undergoing mitral valve replacement (MVR) surgery for infective endocarditis and postoperatively developing TC.

Role of serum lactate to predict early clinical deterioration in hospitalized adult patients with severe acute respiratory syndrome coronavirus-2 infection: A retrospective study.

Background: Hospitalized patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are at risk of further clinical deterioration and poor outcome. In this study, clinical risk factors of the requirement of mechanical ventilation within the first 24 h of hospital admission in coronavirus disease 2019 pneumonia patients have been evaluated.

Methods: In this retrospective study, admission characteristics of SARS-CoV-2-infected patients and risk factors for requiring mechanical ventilation and death within 24 h of admission have been evaluated.