Publications by authors named "S Mahmoudian"

Background: Imbalance in inhibitory and excitatory neurotransmitters have been reported in tinnitus. Acamprosate modulates the excitatory and inhibitory neurotransmission in the nucleus accumbens (NAc). This study aims to assess the effect of Acamprosate on tinnitus, anxiety, depression, and molecular changes in nucleus accumbens (NAc), in Sodium-Salisylate (S-salicylate) model of tinnitus.

View Article and Find Full Text PDF
Article Synopsis
  • Tinnitus is highly prevalent and often linked with increased anxiety, making it important to understand the biological factors behind this connection, specifically the roles of proteins like Neuroligin 2 (NLGN2) and Brain-Derived Neurotrophic Factor (BDNF).
  • This study is the first to explore changes in protein expression in the amygdala, which is crucial for anxiety, in relation to tinnitus-induced anxiety in rats.
  • Results showed that rats with induced tinnitus had higher anxiety levels and increased NLGN2 alongside decreased BDNF in the amygdala compared to controls, highlighting these proteins as potential targets for tinnitus treatment.
View Article and Find Full Text PDF

Background: Early diagnosis of hearing loss and timely interventions are important to minimize the consequences of this condition, especially for children. This research was conducted to analyze the newborn hearing loss screening program in Iran.

Methods: This qualitative study was conducted using the content analysis method and based on the CIPP model in 2023.

View Article and Find Full Text PDF

Tinnitus is a common annoying symptom without effective and accepted treatment. In this controlled experimental study, photobiomodulation therapy (PBMT), which uses light to modulate and repair target tissue, was used to treat sodium salicylate (SS)-induced tinnitus in a rat animal model. Here, PBMT was performed simultaneously on the peripheral and central regions involved in tinnitus.

View Article and Find Full Text PDF

Objective: Despite 6%-20% of the adult population suffering from tinnitus, there is no standard treatment for it. Placenta extract has been used for various therapeutic purposes, including hearing loss. Here, we evaluate the effect of a novel neuroprotective protein composition (NPPC) extract on electrophysiological and molecular changes in the medial geniculate body (MGB) of tinnitus-induced rats.

View Article and Find Full Text PDF