Publications by authors named "S Mahaboob Basha"
Article Synopsis
- Archaeal group II chaperonins, or heat shock proteins (HSPs), are crucial for protein folding and protection during thermal stress in Sulfolobales, especially when faced with thermal shock.
- HSPs maintain structural integrity at neutral pH and varying temperatures but show significant changes at ultra-low pH (pH 2), with HSPα and HSPβ being more thermostable than HSPβ-coh.
- Molecular dynamics simulations support lab findings, revealing stability differences among HSP subtypes and highlighting limitations in acid tolerance despite their thermal resilience.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline, memory impairment, and behavioral alterations. The N-methyl-D-aspartate (NMDA) receptor has emerged as a promising target for AD pharmacotherapy due to its role in the disease's pathogenesis. This study leverages advanced computational methods to screen 80 active constituents of Withania somnifera (Ashwagandha), a traditional herb known for its neuroprotective effects, against the NMDA receptor, using FDA-approved Ifenprodil as a reference.
View Article and Find Full Text PDFAim: This study aimed to evaluate the impact of silibinin as a therapeutic agent on ligature-induced periodontitis in rats with liver cirrhosis.
Materials And Methods: Twenty-five Wistar rats were enrolled in this study. Group A (Control) included eight rats.
Background: Periodontal diseases, including gingivitis and periodontitis, are among the most prevalent oral health issues globally. They compromise the supportive structures of teeth and are influenced by both local and systemic factors. This study aimed to systematically assess the impact of systemic conditions on periodontal health in Malaysian population, addressing the gap in understanding these factors as potential risk factors.
View Article and Find Full Text PDFNeurofilaments are intermediate filaments present in neurons. These provide structural support and maintain the size and shape of the neurons. Dysregulation, mutation, and aggregation of neurofilaments raise the levels of these proteins in the blood and cerebrospinal fluid (CSF), which are characteristic features of axonal damage and certain rare neurological diseases, such as Giant Axonal Neuropathy and Charcot-Mare-Tooth disease.
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