Publications by authors named "S Magnoni"
Article Synopsis
- - The study explores the complex pathophysiology and outcomes of Traumatic Brain Injury (TBI), highlighting that current classifications do not adequately reflect the underlying biological processes involved.
- - Using advanced proteomic techniques, researchers analyzed plasma samples from 88 participants to identify 16 proteins with significant expression differences in TBI patients compared to non-injured controls, focusing on various markers related to neurons, astrocytes, and inflammation.
- - Their findings indicated correlations between specific plasma proteins and brain injury measures, suggesting that certain biomarkers like UCH-L1 and total tau could serve as potential indicators for TBI severity and progression.
Article Synopsis
- Traumatic brain injury (TBI) does not significantly increase plasma levels of phosphorylated tau at serine-181 (p-tau181) within a year post-injury, unlike Alzheimer's disease where p-tau181 is elevated.* -
- In contrast, other biomarkers like total-tau (t-tau), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) were significantly elevated following TBI and were predictive of brain atrophy rates.* -
- The study highlights that while p-tau181 is a relevant marker in Alzheimer's, it doesn't serve as an indicator of neurodegeneration after moderate-to-severe TBI.*
Article Synopsis
- Traumatic brain injury (TBI) is linked to chronic neurodegeneration, potentially due to systemic inflammation signaling the brain and activating microglia, which can lead to widespread brain damage.
- The study, TBI-braINFLAMM, will analyze data from two major TBI research projects—CREACTIVE and BIO-AX-TBI—to assess the relationship between systemic inflammation, injury severity, and ongoing neurodegeneration.
- Ethical approval has been obtained, and findings will be shared through peer-reviewed publications and conferences to enhance understanding and inform future research in this area.
To assess the prevalence of symptoms of Post-Traumatic Stress Disorder (PTSD) in survivors of COVID-19 Acute Respiratory Distress Syndrome that needed ICU care; to investigate risk factors and their impact on the Health-Related Quality of life (HR-QoL). This multicenter, prospective, observational study included all patients who were discharged from the ICU. Patients were administered the European Quality of Life 5 Dimensions 5 Level Version (EQ-5D-5L) questionnaire, the Short-Form Health Survey 36Version 2 (SF-36v2), a socioeconomic question set and the Impact of Event Scale-Revised (IES-R) to assess PTSD.
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