Publications by authors named "S Magge"
Objective: Patients with a history of surgery for single-suture craniosynostosis (SSC) as an infant often wish to participate in sports later in childhood. However, there are no established guidelines from neurosurgeons and craniofacial surgeons to guide parents in which sports their child should or should not participate. Therefore, this study aimed to evaluate the attitudes and practice patterns of experienced neurosurgeons and craniofacial surgeons regarding the counseling of caregivers of these patients about sports participation.
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- Medulloblastoma, the most common malignant brain tumor in children, has distinct subgroups, including WNT-driven and SHH-driven types, and this study focuses on the small molecule MAGMAS inhibitor, BT9, previously shown to impact adult glioblastoma.
- The research involved treating human medulloblastoma cell lines (DAOY and D425) with BT9 and assessing effects on cell proliferation, death, migration, invasion, and metabolic activity through various assays.
- While BT9 significantly reduced cell proliferation and increased death in vitro, it did not improve survival in an in vivo mouse model, indicating potential antitumor effects but limited efficacy in living organisms.
Objective: Cerebral revascularization surgery (CRS) has been used to prevent stroke in children with sickle cell disease (SCD) and cerebral vasculopathy (e.g., moyamoya syndrome).
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- This study analyzes the return-to-work (RTW) rates of patients who underwent surgery for cervical spondylotic myelopathy (CSM) as part of a larger clinical trial comparing different surgical methods.
- Of the 163 patients studied, 68 were employed before surgery, with 66% successfully returning to work within 12 months; the time it took to return varied by surgical type, with laminoplasty (LP) being the quickest.
- The analysis found that a longer hospital stay negatively impacted RTW likelihood, and patients undergoing posterior cervical decompression/fusion (PCDF) reported worse physical outcomes compared to those who had anterior cervical decompression/fusion (ACDF) and LP.
Purpose: Moyamoya disease and syndrome represent rare entities characterized by progressive stenosis and/or occlusion of the intracranial blood vessels. We present our series of patients with moyamoya disease and syndrome stratified by underlying disease and analyze differences in presentation and outcome following surgical revascularization.
Methods: This was an Institutional Review Board (IRB) approved, retrospective review of all patients surgically revascularized by the senior author (SNM) while at Children's National Hospital in Washington, DC.