Real-world clinical results of CGRP monoclonal antibody treatment for medication overuse headache of migraine without abrupt drug discontinuation and no hospitalization.

Background: Abrupt discontinuation of overused medications is standard treatment for medication overuse headache (MOH), but discontinuation is difficult to maintain. The aim was to evaluate the real-world clinical results of anti-calcitonin gene-related peptide monoclonal antibody (CGRP-mAb) treatment for migraine with MOH without abrupt drug discontinuation and no hospitalization.

Methods: Data were collected before starting CGRP-mAb injections (baseline) and 1 month after each injection.

Language Dominance in Left-Handers: Unveiling Left Hemisphere Global Dominance With Specific Right Hemisphere Regional Dominance.

Introduction The degree to which each human brain hemisphere governs specific cognitive processes, such as language and handedness (the preference or dominance of one hand over the other), varies across individuals. Research has explored the nature of language laterality in left-handed (LH) individuals, indicating that left-hemisphere dominance for language is commonly observed across both left- and right-handed populations. Advanced imaging techniques, including functional transcranial Doppler sonography and fMRI, have revealed subtle differences in language lateralization between LH and right-handed (RH) individuals, particularly in semantic processing tasks.

Favorable seizure and developmental outcomes without preoperative intracranial electroencephalography in pediatric patients following epilepsy surgery: A single epilepsy center retrospective study.

Objective: At our institute, most pediatric patients undergo epilepsy surgery following a thorough presurgical evaluation without intracranial electroencephalography (EEG). We conducted an initial validation of our noninvasive presurgical strategy by assessing the seizure and developmental outcomes of 135 children.

Methods: All 135 pediatric patients were <15 years old, had undergone curative surgery, and were followed for at least 2 years postoperatively.

Evaluation of mild cognitive impairment in older patients with essential tremor.

Introduction: Recent studies have reported that essential tremor (ET) presents with not only motor symptoms but also cognitive dysfunction. However, detailed pathological mechanisms remain unclear. Here, we evaluate the characteristics of cognitive changes in older patients.