Publications by authors named "S Macnally"
Background And Purpose: World Health Organization (WHO) grade 2 and 3 diffuse gliomas account for approximately 5% of primary brain tumors. They are invasive and infiltrative tumors and have considerable morbidity, causing progressive neurologic deterioration. The mean survival time is <10 years from diagnosis.
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- Annually, around 480 individuals in Ireland receive a diagnosis of a primary brain tumour, which can negatively impact neurological and cognitive functions, highlighting a significant need for effective rehabilitation.* -
- This study aims to assess the rehabilitation needs of brain tumour patients using a mixed methods approach, including quantitative assessments and qualitative interviews with patients and carers.* -
- By understanding these needs, the research seeks to inform healthcare professionals and policymakers on how to better allocate resources and improve support services for those affected by brain tumours.*
Article Synopsis
- High-energy laser facilities need specialized multilayer coatings on large surfaces, requiring strict control over deposition parameters to achieve desired optical and mechanical qualities.
- The study expands the understanding of how relative humidity affects these coatings, causing shifts in their optical spectra, which are usually limited to a narrow wavelength range.
- Validation of the spectral shift method involved comparing the effects of humidity on single layers with simulated changes due to thickness or refractive index, revealing that humidity primarily influences the refractive index, with SiO being more responsive than HfO.
Article Synopsis
- RET is highlighted as a crucial player in breast cancer brain metastases, with overexpression linked to enhanced cancer cell adhesion and survival in the brain.
- The study utilizes various methods, including pharmacological inhibition and RNA sequencing, to explore RET's functionality and mechanisms in patient-derived tumor samples.
- Findings suggest that targeting RET could be a promising management strategy for breast cancer patients with brain metastases, particularly in those with estrogen receptor-positive tumors.
Monolayers containing subnanometer striations of silica and hafnia to form composite materials at varying ratios are explored as a method to develop high-index dielectric layers with increased laser-induced-damage thresholds (LIDTs). These layers can then be used in multilayer dielectric coatings for short-pulse, high-peak-power laser applications, particularly in regions of the highest electric-field intensity. Fabrication is achieved by means of exposure to two different evaporant vapor plumes, where local exposure to each plume is controlled via shielding to prevent simultaneous exposure.
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