Publications by authors named "S Mackler"
Background: Cannabis use may adversely affect cardiovascular health. Patterns of use by cardiac patients are unknown. We evaluated the prevalence, perceptions, and patterns of cannabis use among cardiac inpatients.
View Article and Find Full Text PDFLoss-of-function in the Parkin protein is thought to play a part in causing neuronal cell death in patients with Parkinson's disease. This study explores the effect of Parkin degradation, via the overexpression of nucleus accumbens 1 (NAC1), on cell viability. It was found that NAC1 and Parkin are co-localized within the cell and interact with one another, leading to a decrease in Parkin levels.
View Article and Find Full Text PDFProtein degradation is a critical component of cellular maintenance. The intracellular translocation and targeting of the Ubiquitin Proteasome System (UPS) differentially coordinates a protein's half-life and thereby its function. Nucleus Accumbens 1 (NAC1), a member of the Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad complex (POZ/BTB) family of proteins, participates in the coordinated proteolysis of synaptic proteins by mediating recruitment of the UPS to dendritic spines.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the phenomenon of sour ageusia, where two patients could not perceive sour tastes but still responded normally to bitter, sweet, and salty flavors.
- Biopsies were taken from the patients and sour-normal individuals, revealing that certain ion channels associated with sour taste (ASICs and PKDs) were absent in the patients but present in the controls.
- This research implies that ASICs and PKDs play a crucial role in sour taste perception, presenting the first case of sour ageusia in humans and suggesting a distinct cellular pathway for sour taste separate from other flavors.
Article Synopsis
- NAC1 is identified as a corepressor for various POZ/BTB transcriptional repressor proteins, affecting gene regulation in both neuronal and non-neuronal cells.
- In experiments, NAC1 showed the ability to reverse transcriptional inhibition caused by multiple Gal4 fusion proteins, indicating its role in modulating transcriptional activity.
- The study also revealed that NAC1 selectively interacts with other POZ/BTB proteins, confirming its involvement in protein-protein interactions, particularly in central nervous system tissues.