Hydroxyacid Oxidase 1, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Luminal Breast Cancer.

Breast cancer (BC), which remains the most prevalent malignancy among women, is characterised by significant heterogeneity across its molecular subtypes. Oestrogen receptor-positive (ER+) (luminal) BC represents approximately 75% of cases, and despite advancements in treatment there remains around a 40% recurrence rate. Cellular uptake of glutamine is conducted by solute carriers (SLCs), which are significantly associated with outcome in luminal BC.

Higher Apparent Gas Transfer Velocities for CO Compared to CH in Small Lakes.

Large greenhouse gas emissions occur via the release of carbon dioxide (CO) and methane (CH) from the surface layer of lakes. Such emissions are modeled from the air-water gas concentration gradient and the gas transfer velocity (). The links between and the physical properties of the gas and water have led to the development of methods to convert between gases through Schmidt number normalization.

Diversity in Genetic Regulation of Bacterial Fimbriae Assembled by the Chaperone Usher Pathway.

Bacteria express different types of hair-like proteinaceous appendages on their cell surface known as pili or fimbriae. These filamentous structures are primarily involved in the adherence of bacteria to both abiotic and biotic surfaces for biofilm formation and/or virulence of non-pathogenic and pathogenic bacteria. In pathogenic bacteria, especially Gram-negative bacteria, fimbriae play a key role in bacteria-host interactions which are critical for bacterial invasion and infection.

Regulating MR Safety Standards.

Magnetic resonance (MR) imaging uses magnetic fields and radio waves to generate an image of the body. Though it is considered safe because it does not emit ionizing radiation, the strong magnetic fields produced by the MR scanner require unique safety considerations. The American College of Radiology (ACR) has provided guidance documents on MR safety since 2002 and recently updated and reorganized these documents into the ACR Manual on MR Safety.

Optimised Heterologous Expression and Functional Analysis of the F1-Capsular Antigen Regulator Caf1R.

The bacterial pathogen, , has caused three historic pandemics and continues to cause small outbreaks worldwide. During infection, assembles a capsule-like protective coat of thin fibres of Caf1 subunits. This F1 capsular antigen has attracted much attention due to its clinical value in plague diagnostics and anti-plague vaccine development.