Publications by authors named "S MaaSS"
Bacterial small proteins impact diverse physiological processes, however, technical challenges posed by small size hampered their systematic identification and biochemical characterization. In our quest to uncover small proteins relevant for pathogenicity, we previously identified YjiS, a 54 amino acid protein, which is strongly induced during this pathogen's intracellular infection stage. Here, we set out to further characterize the role of YjiS.
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on evaluating a specialized clinic for children suspected of having hereditary thoracic aortic disease (HTAD), particularly Marfan Syndrome (MFS), from 1998 to 2018.
- Out of 355 children evaluated, 89 were diagnosed with HTAD, showing a diagnostic yield of 21%, with younger age, specific symptoms, and findings being strong predictors for MFS and HTAD.
- The findings suggest that early detection and referral to specialized clinics can lead to timely treatment, surveillance, and potentially reduce serious complications like acute aortic events and mortality.
Article Synopsis
- Gracilibacteria are a group of bacteria that are part of the candidate phyla radiation (CPR), characterized by small size and incomplete metabolic pathways, indicating a potential symbiotic lifestyle, and their roles in ecosystems, especially in groundwater, are still largely unknown.
- The study utilized metagenomic and metaproteomic analyses over a 12-day period at a cold-water geyser in Germany to observe the activity and genetic expression of Gracilibacteria, identifying multiple genomes and their interactions with other microbial communities.
- The findings revealed that Gracilibacteria possess genomic traits suggesting limited metabolic functions and a reliance on host organisms for survival, as indicated by a high number of genes related to cell interaction and motility.
Background And Objective: There are multiple pharmacological treatment options for motor symptoms of Parkinson's disease (PD). These comprise multiple drug classes which are approved for the condition, including levodopa, dopamine agonists, COMT inhibitors, MAO-B inhibitors, NMDA-receptor antagonists, anticholinergics, and others. Some of the drugs are approved for monotherapy and combination therapy while others are only approved as adjunctive therapy to levodopa.
View Article and Find Full Text PDFLGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic K1 Loss and Increased Action Potential Broadening.
Neurol Neuroimmunol Neuroinflamm
September 2024
Article Synopsis
- Autoantibodies against LGI1 are linked to autoimmune encephalitis, impacting the limbic system and causing seizures and memory issues.
- The study focused on how these autoantibodies influence synaptic structure and function, revealing effects on neurotransmitter release.
- Results showed that LGI1 autoantibodies enhanced neurotransmission by increasing release probability but did not affect presynaptic calcium channels; however, they reduced certain potassium channel densities.