Publications by authors named "S MARQUE"
Article Synopsis
- Dynamic covalent bonding (DCB) is gaining attention in materials science for its potential in drug development targeting tropical parasitic diseases like malaria and bilharziasis.
- Recent findings indicate that certain alkoxyamines, which showcase DCB, demonstrate significant effectiveness against these parasites, achieving 100% mortality in worms and specific inhibitory concentrations.
- The research utilizes both enzymatic-physical and enzymatic-chemical activation methods to enhance the efficacy of alkoxyamines, with the enzymatic component ensuring targeted drug action.
Article Synopsis
- Age acceleration/deceleration (Age A/D) can be assessed through various clinical measurements of skin conditions, which may not align with a person's chronological age.
- A study involving 360 women identified three distinct skin classes based on attributes like dryness, elasticity, and oiliness, and examined how these related to the levels of specific proteins in the skin.
- The research highlighted that higher levels of insulin degrading enzyme (IDE) in the stratum corneum are linked to slower skin aging, suggesting that molecular markers could help predict age-related skin changes.
In search of better specificity and lower chances of resistance, protease-activatable alkoxyamine prodrugs to fight cancer have been proposed. These molecules are made of a peptide linked to an alkoxyamine. Proteolysis of the peptide converts the stable prodrug at 37 °C to a metastable alkoxyamine that spontaneously homolyzes into two free radicals: a stable nitroxide and a very reactive alkyl radical.
View Article and Find Full Text PDFIonizing radiation induced transformations in materials were monitored through tracking of the generation and degradation processes of radical species. Consequently, the types and quantities of radicals were determined by electron spin resonance (ESR). Subsequently, differential scanning calorimetry (DSC) was utilized to assess the impact of irradiation on the material crystallinity.
View Article and Find Full Text PDFThe expansion of drug resistant parasites sheds a serious concern on several neglected parasitic diseases. Our recent results on cancer led us to envision the use of peptide-alkoxyamines as a highly selective and efficient new drug against schistosome adult worms, the etiological agents of schistosomiasis. Indeed, the peptide tag of the hybrid compounds can be hydrolyzed by worm's digestive enzymes to afford a highly labile alkoxyamine which homolyzes spontaneously and instantaneously into radicals-which are then used as a drug against Schistosome adult parasites.
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