Development of ICF-based patient-reported outcome and experience measures to study social participation among people with chronic diseases: a mixed-methods protocol.

Introduction: Living with a chronic disease impacts many aspects of life, including the ability to participate in activities that enable interactions with others in society, that is, social participation (SP). Despite efforts to monitor the quality of care and life of chronically ill people in Belgium, no disease-specific patient-reported measures (PRMs) have been used. These tools are essential to understand SP and to develop evidence-based recommendations to support its improvement.

RAD51 recruitment but not replication fork stability associates with PARP inhibitor response in ovarian cancer patient-derived xenograft models.

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat mutant cancers. Although PARPi sensitivity has been attributed to homologous recombination (HR) defects, other roles of HR factors have also been linked to response to PARPi, including replication fork protection. In this study, we investigated PARPi sensitivity in ovarian cancer patient-derived xenograft (PDX) models in relation to HR proficiency and replication fork protection.

Quantitative proteomics reveals oxygen-induced adaptations in TA2.A1 microaerobic chemostat cultures.

The thermoalkaliphile possesses a highly branched respiratory chain. These primarily facilitate growth at a wide range of dissolved oxygen levels. The aim of this study was to investigate the regulation of respiratory chain.

Using Real-World Data to Assess the Association of Retinal Detachment With Topical Pilocarpine Use.

Purpose: To examine the association between topical pilocarpine and the risk of new-onset rhegmatogenous retinal detachment (RRD).

Design: Retrospective clinical cohort study.

Methods: We used an aggregated electronic health records research network, TriNetX, to examine the risk of RRD (ICD-10: H33.

Subtle or Covert Abuse Within Intimate Partner Relationships: A Scoping Review.

Intimate partner violence (IPV) is a global health problem enacted with varying degrees of severity, leading to mental and physical damage. Despite the acknowledgment that perpetration can be enacted in a subtle or covert way, there is a paucity of literature defining and describing such subtle abuse. Consequently, understanding about the behaviors and impacts of subtle abuse is limited, and there is a potential inability by therapists to recognize it in their clients.