Publications by authors named "S M de Boer"
Bunyaviruses: Expression of Recombinant Glycoproteins from Insect Cells.
Methods Mol Biol
December 2024
High-density suspension cultures of insect cells offer a scalable and serum-free system for the expression of recombinant proteins. Rift Valley fever virus (RVFV), an arthropod-borne virus spread by mosquitoes, contains two envelop glycoproteins Gn and Gc. These glycoproteins are crucial for eliciting neutralizing antibodies that can offer protection against RVFV infection.
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- Indigenous maize varieties from eastern North America have significantly influenced breeding programs, but their origins remain unclear.
- Paleogenomic studies trace maize's journey to this region, indicating multiple migrations from Mexico, especially towards the northern U.S., including a notable path from the Southwest.
- Analysis shows that ancient Ozark maize specimens exhibit a unique wx1 gene linked to starch metabolism, demonstrating how selective pressures shaped maize domestication and connecting these varieties to the Northern Flints, vital for today's commercial maize.
This study aims to determine a margin and robustness setting for treating locally advanced cervical cancer (LACC) with a library-of-plans (LoP) based online-adaptive intensity-modulated proton therapy (IMPT).We analyzed 13 LACC patients with delineated planning and weekly repeat CT scans (reCTs). For each patient, 120 IMPT treatments of 25 fractions were simulated with a LoPs approach.
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- Behavioral variant frontotemporal dementia (bvFTD) leads to significant changes in personality and behavior, but there’s a lack of consensus on effective drug treatments despite high symptom burden for patients and caregivers.
- A survey of 48 experts in dementia treatment identified that disinhibition and compulsive behaviors are the primary symptoms targeted, with suggested medications including atypical antipsychotics and SSRIs.
- The findings indicate varied treatment approaches among professionals, highlighting the need for more research to develop consensus on effective pharmacological strategies for managing bvFTD symptoms.
Frontotemporal dementia (FTD) is one of the leading causes of young-onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure.
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