Publications by authors named "S M Zoellner"
Background: A noninvasive ventilation (NIV) mask has been designed to deliver NIV with expiratory washout to improve efficacy of ventilation by optimizing clearance of expired gases from the anatomic dead space. This study compared the performance and comfort of a novel investigational mask with expiratory washout with a conventional mask during NIV therapy.
Methods: In this pilot crossover study, participants with severe stable COPD attended a single visit to receive bi-level NIV through 2 masks; the investigational mask with expiratory washout and a conventional mask.
Background: The PNPLA3-rs738409-G, TM6SF2-rs58542926-T, and HSD17B13-rs6834314-A polymorphisms have been associated with cirrhosis, hepatic decompensation, and HCC. However, whether they remain associated with HCC and decompensation in people who already have cirrhosis remains unclear, which limits the clinical utility of genetics in risk stratification as HCC is uncommon in the absence of cirrhosis. We aimed to characterize the effects of PNPLA3, TM6SF2, and HSD17B13 genotype on hepatic decompensation, HCC, and liver-related mortality or liver transplant in patients with baseline compensated cirrhosis.
View Article and Find Full Text PDFBackground: Clozapine can be associated with significant side effects and tolerability issues. Hyperhidrosis occurs less commonly and is unanticipated by clinicians because of clozapine's significant anticholinergic activity.
Case Report: A 34-year-old female developed clozapine-induced nocturnal, generalized hyperhidrosis following initial titration to 400 mg/day.
Article Synopsis
- Understanding the patterns of drug-gene interactions (DGIs) is crucial for integrating pharmacogenetics (PGx) into clinical practice, as few studies have confirmed these interactions in patients with specific genotypes and prescriptions.
- A retrospective chart review found that 75% of patients were prescribed medications with PGx guidelines, with up to 60% having at least one DGI, mainly occurring in outpatient settings, and proton pump inhibitors being the most commonly involved medications.
- The findings highlight the prevalence of multigene interactions, suggesting that panel PGx testing could be a valuable strategy for clinical implementation, as well as indicate key stakeholders for DGI prescribing workflows.
Background: The risk of arterial diseases may be elevated among family members of individuals having multifocal fibromuscular dysplasia (FMD). We sought to investigate the risk of arterial diseases in families of individuals with FMD.
Methods: Family histories for 73 probands with FMD were obtained, which included an analysis of 463 total first-degree relatives focusing on FMD and related arterial disorders.