Publications by authors named "S M Wolff"
In the ACC/AHA guidelines, the presence of symptoms plays a central role in determining timing surgery in primary mitral regurgitation (MR). Studies have shown a disconnect between the severity of MR and symptoms. The purpose of this study is to assess risk factors for symptoms in patients with chronic primary MR.
View Article and Find Full Text PDFTrisomy of human chromosome 21 (Ts21) individuals present with a spectrum of low bone mineral density (BMD) that predisposes this vulnerable group to skeletal injuries. To determine the bone regenerative capacity of Down syndrome (DS) mice, male and female Dp16 and Ts65Dn DS mice underwent amputation of the digit tip (the terminal phalanx (P3)). This is a well-established mammalian model of bone regeneration that restores the amputated skeletal segment and all associated soft tissues.
View Article and Find Full Text PDFSpherical Manifolds Capture Drug-Induced Changes in Tumor Cell Cycle Behavior.
Pac Symp Biocomput
December 2024
CDK4/6 inhibitors such as palbociclib block cell cycle progression and improve outcomes for many ER+/HER2- breast cancer patients. Unfortunately, many patients are initially resistant to the drug or develop resistance over time in part due to heterogeneity among individual tumor cells. To better understand these mechanisms of resistance, we used multiplex, single-cell imaging to profile cell cycle proteins in ER+ breast tumor cells under increasing palbociclib concentrations.
View Article and Find Full Text PDFArticle Synopsis
- Complexes featuring a doubly reduced carbonite ligand connect a nickel(II) center with a transition metal(II) ion (like Fe, Co, or Zn) have been synthesized.
- NMR spectroscopy and DFT calculations show that the carbonite ligand shows flexible coordination in non-coordinating solvents.
- The [Ni-CO-Fe] complex mirrors an intermediate in CO-conversion by the [Ni,Fe]-CODH enzyme, and findings suggest transition metals lower reduction potential while increasing C-O bond cleavage propensity, hinting at the functional choice of iron(II) in the enzyme's active site.
Moiré Lattice of Twisted Bilayer Graphene as Template for Non-Covalent Functionalization.
Angew Chem Int Ed Engl
November 2024
We present a novel approach to achieve spatial variations in the degree of non-covalent functionalization of twisted bilayer graphene (tBLG). The tBLG with twist angles varying between ~5° and 7° was non-covalently functionalized with 1,4,5,8,9,11-hexaazatriphenylenehexacarbonitrile (HATCN) molecules. Our results show a correlation between the degree of functionalization and the twist angle of tBLG.
View Article and Find Full Text PDF