Publications by authors named "S M Woerner"
Therapy adherence can significantly influence the outcome of cancer patients. The prospective, non-interventional CARO study (NCT02970747) investigated adherence, effectiveness, and safety of carfilzomib in patients with relapsed/refractory multiple myeloma (RRMM) in the German real-world setting. In total, 359 patients were included at 69 sites.
View Article and Find Full Text PDFQuantum computers process information with the laws of quantum mechanics. Current quantum hardware is noisy, can only store information for a short time and is limited to a few quantum bits, that is, qubits, typically arranged in a planar connectivity. However, many applications of quantum computing require more connectivity than the planar lattice offered by the hardware on more qubits than is available on a single quantum processing unit (QPU).
View Article and Find Full Text PDFArticle Synopsis
- Quantum computing offers capabilities that surpass classical computers, but current quantum machines produce noisy outputs, complicating result accuracy.
- This study assesses how noise affects bit string sampling and its consequences for optimization and machine learning tasks.
- By quantifying the sampling overhead and relating it to layer fidelity, the research establishes provable bounds on noise-free expectation values, validated through experiments on quantum computers with up to 127 qubits, showing good alignment with theoretical outcomes.*
In preclinical models, α-difluoromethylornithine (DFMO), an ornithine decarboxylase (ODC) inhibitor, delays the onset of type 1 diabetes (T1D) by reducing β cell stress. However, the mechanism of DFMO action and its human tolerability remain unclear. In this study, we show that mice with β cell ODC deletion are protected against toxin-induced diabetes, suggesting a cell-autonomous role of ODC during β cell stress.
View Article and Find Full Text PDFObjectives: Achieving optimal glycemic outcomes in young children with type 1 diabetes (T1D) is challenging. This study examined the durability of continuous glucose monitoring (CGM) coupled with a family behavioral intervention (FBI) to improve glycemia.
Study Design: This one-year study included an initial 26-week randomized controlled trial of CGM with FBI () and CGM alone () compared with blood glucose monitoring (BGM), followed by a 26-week extension phase wherein the BGM Group received the CGM+FBI () and both original CGM groups continued this technology.