Publications by authors named "S M Wiesner"
A fascinating aspect of nanoscale ferroelectric materials is the emergence of topological polar textures, which include various complex and stable polarization configurations. The manipulation of such topological textures through external stimuli like electric fields holds promise for advanced nanoelectronics applications. There are, however, several challenges to reach potential applications, among which reliably creating and controlling these textures at the nanoscale on silicon, and with lead-free compounds.
View Article and Find Full Text PDFThe chlamydial deubiquitinase Cdu1 of the obligate intracellular human pathogenic bacterium Chlamydia trachomatis plays important roles in the maintenance of chlamydial infection. Despite the structural similarities shared with its homologue Cdu2, both DUBs display remarkable differences in their enzymatic activity towards poly-UB chain substrates. Whereas Cdu1 is highly active towards K48- and K63- poly-UB chains, Cdu2 activity is restricted mostly to mono-UB substrates.
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- Left ventricular (LV) function is linked to the elasticity of the ascending aorta (AA), with stiffness in the AA potentially leading to reduced LV performance in patients with heart failure with preserved ejection fraction (HFpEF).
- A study using the Living Left Heart Human Model simulated different scenarios, including models with elastic and stiff AAs, as well as a stiff AA with a free LV apex.
- Results indicate that allowing the LV apex to move freely could counteract the negative effects of a stiff AA, suggesting a potential therapeutic approach to improve LV function in HFpEF patients.
Article Synopsis
- During systole, the left ventricle shortens, moving the aortic root and stretching the ascending aorta, which impacts heart function.
- A study revealed that stiffening of the ascending aorta increases stress in the left ventricle and leads to decreased muscle strain, particularly in the septal area.
- Overall, aortic stiffening negatively affects left ventricular function, but increasing myofiber contractility could help recover some lost stroke volume despite persistent reductions in specific muscle strains.
Background: The Clavien-Madadi classification is a novel instrument for the assessment and grading of unexpected events in pediatric surgery, based on the Clavien-Dindo classification. The system has been adjusted to better fit the pediatric population in a prospective single-center study. There is a need now to validate the Clavien-Madadi classification within an international expert network.
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