Publications by authors named "S M Van Nostrand"
Group B streptococcus (GBS) is the leading cause of bacterial sepsis and meningitis in neonates worldwide, but brain abscess secondary to GBS is extremely rare. While temporal brain abscesses have been described as a sequelae of otogenic infections in children and adults, such a presentation has not been described in neonates. An 8-day-old female infant presented with a fever and irritability along with bilateral purulent otorrhea.
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- * Multi-omics analyses of blood and tissue samples from a clinical trial revealed that higher immune scores correlate with better responses to ICIs, while certain immune cells, like regulatory T cells, negatively impact survival.
- * Variations in immune cell density and proximity to tumor cells influence survival outcomes, and soluble proteins found in the blood could serve as indicators for treatment effectiveness and overall survival in SqNSCLC patients.
Chimeric antigen receptor T cells (CAR-Ts) have remarkable efficacy in liquid tumors, but limited responses in solid tumors. We conducted a Phase I trial (NCT02107963) of GD2 CAR-Ts (GD2-CAR.OX40.
View Article and Find Full Text PDFBackground: Immune challenge is known to increase heat stroke risk, although the mechanism of this increased risk is unclear.
Objectives: We sought to understand the effect of immune challenge on heat stroke pathology.
Patients/methods: Using a mouse model of classic heat stroke, we examined the impact of prior viral or bacterial infection on hematological aspects of recovery.