Diagnostic Accuracy of S100B in Predicting Intracranial Abnormalities on CT Imaging Following Mild Traumatic Brain Injury: A Systematic Review and Meta-analysis.

Traumatic brain injury (TBI) is a major cause of health loss and disabilities globally, burdening health care systems. Mild TBI is a common cause of emergency department visits. Computed tomography (CT) scans are the mainstay for acute TBI imaging.

Improved Dipole Source Localization from Simultaneous MEG-EEG Data by Combining a Global Optimization Algorithm with a Local Parameter Search: A Brain Phantom Study.

Dipole localization, a fundamental challenge in electromagnetic source imaging, inherently constitutes an optimization problem aimed at solving the inverse problem of electric current source estimation within the human brain. The accuracy of dipole localization algorithms is contingent upon the complexity of the forward model, often referred to as the head model, and the signal-to-noise ratio (SNR) of measurements. In scenarios characterized by low SNR, often corresponding to deep-seated sources, existing optimization techniques struggle to converge to global minima, thereby leading to the localization of dipoles at erroneous positions, far from their true locations.

Sensor-Head Distance and Signal Strength in Whole-Head Magnetoencephalography: Report of 996 Patients With Epilepsy.

Purpose: Although the sensor-to-head distance is theoretically known to affect the signal strength in magnetoencephalography (MEG), these values have not been reported for a whole-head MEG system in a large population. We measured the distance and signal strength in 996 patients with epilepsy.

Methods: The MEG sensor array consisted of 102 measurement sites, each of which had two gradiometers and one magnetometer.

Imaging and anesthesia protocol optimization in sedated clinical resting state fMRI.

Background And Purpose: The quality of resting-state functional MRI (rs-fMRI) under anesthesia is variable and there are no guidelines on optimal image acquisition or anesthesia protocol. We aim to identify the factors that may lead to compromised clinical rs-fMRI under anesthesia.

Materials And Methods: In this cross-sectional study, we analyzed clinical rs-fMRI data acquired under anesthesia from 2009-2023 at Massachusetts General Hospital.

Delays in latencies of median-nerve evoked magnetic fields in patients with succinic semialdehyde dehydrogenase deficiency.

Objective: Succinic semialdehyde dehydrogenase deficiency (SSADHD) is a genetic disorder resulting in abnormal regulation of γ-aminobutyric acid, lipid metabolism, and myelin biogenesis, leading to ataxia, seizures, and cognitive impairment. Since the myelin sheath is thinner in a murine model of SSADHD compared to a wild type, we hypothesized that this also holds for human brain. We tested whether the conduction velocity in the somatosensory pathway is accordingly delayed.