Publications by authors named "S M Stietz"
The aim of this study is to describe genetic variation in the TNF promoter in the ethnically diverse population of Misiones, north-eastern Argentina. We analysed 210 women including 66 Amerindians of the Mbya-Guarani ethnic group and 144 white-admixed individuals from urban and rural areas of Misiones. Their DNA samples were surveyed for TNF polymorphisms -376 A/G, -308 A/G -244 A/G and -238 A/G by PCR amplification and direct sequencing and for the Amerindian marker -857 C/T by real-time PCR.
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- HPV is linked to cervical cancer, but not all women infected develop the disease; SNPs in immune and cytokine genes may influence this risk.
- The study focused on TNF-α SNPs in urban women from Posadas, Argentina, comparing 56 cervical cancer cases with 113 controls through genetic analysis.
- Results indicated that the TNFα-307A variant significantly increases cancer risk, while the TNFα-375A variant appeared protective and was only found in controls, suggesting complex interactions between immune gene variations and cervical cancer susceptibility.
Calcium nephrolithiasis is the most common form of renal stone disease, with calcium oxalate (CaOx) being the predominant constituent of renal stones. Current in vitro evidence implicates osteopontin (OPN) as one of several macromolecular inhibitors of urinary crystallization with potentially important actions at several stages of CaOx crystal formation and retention. To determine the importance of OPN in vivo, hyperoxaluria was induced in mice targeted for the deletion of the OPN gene together with wild-type control mice.
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