Publications by authors named "S M Steinberg"
Introduction: Opioid use disorder is a chronic illness with significant morbidity and mortality. Opioid agonists, like buprenorphine, are commonly used to prevent relapse. Recent changes in buprenorphine legislation are expected to increase prescription and guidelines recommend its continuation during the perioperative period for many patients.
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- * The study reveals that most ATM-deficient T-LBL cultures have various genomic alterations in the PTEN gene, resulting in the absence of functional PTEN protein and constant activation of AKT signaling.
- * These lymphomas are sensitive to the AKT inhibitor MK-2206, indicating they rely on pAKT signaling for survival, and this loss of PTEN expression and activation of AKT is not seen in non-cancerous thymocytes.
Pregnancy Outcomes in Grand Multiparity Women With Antiphospholipid Antibodies.
Am J Reprod Immunol
November 2024
Article Synopsis
- The study investigates the pregnancy outcomes of women with antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL) who have had five or more pregnancies (grand multiparity) and compares them to two control groups: those with fewer pregnancies and those without aPL/APS.
- Results showed that while most pregnancy-related parameters were similar across the groups, grand multiparity women with aPL/APS had higher rates of obstetric APS diagnosis, older maternal age, higher body mass index (BMI), more cases of polyhydramnios, and delivered larger babies.
- The conclusions suggest that the perinatal outcomes for grand multiparity women with aPL/APS are not worse than those of their counterparts
Underrepresented populations' participation in clinical trials remains limited, and the potential impact of genomic variants on drug metabolism remains elusive. This study aimed to assess the pharmacokinetics (PK) and pharmacogenomics (PGx) of ribociclib in self-identified Black women with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2) advanced breast cancer. LEANORA (NCT04657679) was a prospective, observational, multicenter cohort study involving 14 Black women.
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