Publications by authors named "S M Stahl"
Nickel-catalyzed cross-electrophile coupling (XEC) reactions of (hetero)aryl electrophiles represent appealing alternatives to palladium-catalyzed methods for biaryl synthesis, but they often generate significant quantities of homocoupling and/or proto-dehalogenation side products. In this study, an informer library of heteroaryl chloride and aryl bromide coupling partners is used to identify Ni-catalyzed XEC conditions that access high selectivity for the cross-product when using equimolar quantities of the two substrates. Two different catalyst systems are identified that show complementary scope and broad functional-group tolerance, and time-course data suggest that the two methods follow different mechanisms.
View Article and Find Full Text PDFMethanolation of olefins is introduced as a new low-pressure synthetic pathway to C1 elongated alcohols. Formally, HCOH is added to the C=C bond in a 100 % atom efficient manner. Mechanistically, the overall transformation occurs as a tandem reaction sequence by combining the dehydrogenation of methanol to syngas at a CO : H ratio of 1 : 2 with subsequent hydroformylation to the corresponding aldehyde and its final hydrogenation to the alcohol.
View Article and Find Full Text PDFSacrificial anodes composed of inexpensive metals such as Zn, Fe, and Mg are widely used to support electrochemical nickel-catalyzed cross-electrophile coupling (XEC) reactions, in addition to other reductive electrochemical transformations. Such anodes are appealing because they provide a stable counter-electrode potential and typically avoid interference with the reductive chemistry. The present study outlines the development of an electrochemical Ni-catalyzed XEC reaction that streamlines access to a key pharmaceutical intermediate.
View Article and Find Full Text PDFTreatment Outcomes in Awake Endoscopy With Advanced Programming in Hypoglossal Nerve Stimulation.
Ann Otol Rhinol Laryngol
February 2025
Article Synopsis
- HNS Treatment Context
- : Hypoglossal nerve stimulation (HNS) is a viable treatment for moderate-to-severe obstructive sleep apnea, and post-implant procedures like awake endoscopy with advanced programming (AEAP) can enhance the effectiveness and comfort of this treatment.
- Study Methods
- : The study analyzed 17 patients who underwent AEAP to assess their apnea hypopnea index (AHI) responses, categorizing them into two groups based on their NT-AHI, using various statistical methods to determine significance.
- Key Findings and Conclusion
- : Most patients who initially struggled with NT-AHI reduction showed improvements after AEAP, particularly those without specific airway issues; the research emphasizes the importance of
Article Synopsis
- The Resource Centers for Minority Aging Research (RCMAR) program, part of the National Institute on Aging, has successfully advanced minority aging research and diversified the scientific workforce over nearly 30 years.
- The article outlines the program's development, focusing on enhancing health disparities research methods and preparing future scholars through comprehensive career development and supportive communities.
- It concludes by discussing RCMAR's successes, ongoing challenges, and future growth opportunities in responding to evolving political and research contexts while maintaining its core mission.