Publications by authors named "S M Spinola"
Childhood early oral ageing syndrome: prevalence and association with possible aetiological factors and consequences for the vertical dimension of occlusion: protocol for a cross-sectional study.
BMJ Open
December 2024
Introduction: Childhood early oral ageing syndrome (CEOAS) is a condition involving oral abnormalities resulting from systemic diseases of different origins that are related to the current lifestyle of the paediatric population. Enamel defects associated with intrinsic and extrinsic factors promote the early loss of tooth structure at an accelerated pace, with negative impacts on function, aesthetics and quality of life. The aim of the study is to identify the prevalence of early tooth wear in childhood and its severity using the CEOAS index, which is a tool for the diagnosis of the condition and for epidemiological surveys, involving the investigation of abnormalities of the oral cavity in the paediatric population and possible factors associated with the severity of the condition.
View Article and Find Full Text PDFPremature, non-physiological tooth wear in childhood has numerous repercussions for oral health. This is a growing problem with multifactorial causes and associated with the current lifestyle. The introduction of new concepts and indices is crucial for enhancing the understanding and management of dental conditions.
View Article and Find Full Text PDFArticle Synopsis
- Chancroid is a sexually transmitted infection that causes painful genital ulcers and is now linked to non-sexually transmitted skin ulcers in children, particularly in areas where yaws is common.! -
- The review analyzes the differences between genital and cutaneous ulcer strains, their clinical features, diagnosis, and treatment, while highlighting the decline of genital ulcers compared to the persistence of skin ulcers.! -
- Effective management strategies include targeted treatment for at-risk populations and addressing environmental factors to eliminate cutaneous ulcers in children, with a focus on hygiene and identifying additional infection reservoirs.!
Article Synopsis
- Chancroid, a genital ulcer disease causing painful skin ulcers, is linked to a bacterium that uses a specific receptor, HgbA, to acquire heme from hosts, crucial for its disease progression.
- The study involved creating a mutant strain (35000HPΔΔ) that showed growth issues when using human hemoglobin for iron; however, trials with human volunteers showed both the mutant and the parent strain produced similar skin reactions, indicating that the YfeABCD transporter isn't essential for the bacteria's virulence.
- The research suggests that despite the deletion of the YfeABCD system, the bacteria can rely on alternative transport systems like HbpA and others to manage heme transport, highlighting the redundancy of vir
Aims: Despite a strong theoretical link between opioid craving and pain, little is known about the temporal relationship between pain and craving and the acute experience of pain in the context of methadone treatment. Using a cross-over design, the current study evaluated the time course of pain and craving and objective experience of pain as a function of the last methadone dose.
Methods: Participants (n = 20) presented for the study in the morning and either received methadone dose as scheduled or delayed dose until the afternoon.