Publications by authors named "S M Sheriff"
Purpose To develop and evaluate the performance of NNFit, a self-supervised deep-learning method for quantification of high-resolution short echo-time (TE) echo-planar spectroscopic imaging (EPSI) datasets, with the goal of addressing the computational bottleneck of conventional spectral quantification methods in the clinical workflow. Materials and Methods This retrospective study included 89 short-TE whole-brain EPSI/GRAPPA scans from clinical trials for glioblastoma (Trial 1, May 2014-October 2018) and major-depressive-disorder (Trial 2, 2022- 2023). The training dataset included 685k spectra from 20 participants (60 scans) in Trial 1.
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- Severe acute symptomatic hypocalcemia is a serious health issue often presenting as painful spasms, and innovative methods like metabolomics and genetic profiling may help identify those at risk and guide treatments.
- The study aimed to determine the prevalence of hypocalcemia in urban Kano by analyzing retrospective data from hospital patients in 2023, finding a prevalence rate of 52.2%, with females being more affected than males.
- Results highlight the urgent need for improved understanding of hypocalcemia's genetic factors and the potential for developing targeted public health initiatives for high-risk populations.
Improving the diffraction quality of heat-shock protein 47 crystals.
Acta Crystallogr F Struct Biol Commun
November 2024
Heat-shock protein 47 (HSP47) is a potential target for inhibitors that ameliorate fibrosis by reducing collagen assembly. In an effort to develop a structure-based drug-design system, it was not possible to replicate a previous literature result (PDB entry 4au4) for apo dog HSP47; instead, crystal forms were obtained in which pairs of dog HSP47 molecules interacted through a noncleavable C-terminal His-tag to build up tetramers, all of which had multiple molecules of HSP47 in the asymmetric unit and none of which diffracted as well as the literature precedent. To overcome these difficulties, a two-pronged approach was followed: (i) the His-tag was moved from the C-terminus to the N-terminus and was made cleavable, and (ii) Adnectin (derived from the tenth domain of human fibronectin type III) crystallization chaperones were developed.
View Article and Find Full Text PDFObjective: To evaluate characteristics of matched and unmatched general surgery residency (GSR) applicants.
Background: Given the recent change of the United States Medical Licensing Exam Step 1 grading to pass/fail, understanding the factors that influence GSR match success is integral to identifying potential interventions to improve match rates for diverse medical students.
Methods: Retrospective review of GSR National Residency Matching Program (NRMP) applicant and Accreditation Council for Graduate Medical Education (ACGME) active resident data between 2011 and 2022.