Publications by authors named "S M Shali"
Article Synopsis
- Researchers examined metabolomic biomarkers as potential indicators of residual risk in patients with coronary atherosclerotic disease (CAD) undergoing moderate lipid-lowering therapy.
- The study involved 2560 patients, analyzing their serum metabolomic profiles, linking specific metabolites to CAD severity measured by Gensini score and cardiac troponin T levels.
- Key findings showed that certain metabolites, particularly triglycerides and apolipoprotein B, had stronger associations with CAD severity than traditional cholesterol markers, and a metabolomic index related to CAD severity was linked to a significantly higher risk of adverse cardiac events during follow-up.
Hyperuricemia is a common metabolic disorder with severe complications. We aimed to develop a mouse model for spontaneous hyperuricemia. Uox mouse model was generated on C57BL/6J background by deleting exon 2-4 of Uox using the CRISPR/Cas9 system.
View Article and Find Full Text PDFBackground: Early diagnosis and treatment effectiveness of early-onset coronary artery disease (EOCAD) are crucial, and non-invasive predictive biomarkers are needed for young adults. We aimed to evaluate the usefulness of the triglyceride-glucose (TyG) index, a novel marker of insulin resistance, in identifying young CAD patients and predicting their risk of developing target lesion failure (TLF).
Methods: We recruited EOCAD patients (luminal narrowing ≥ 70%) and controls free from CAD (luminal narrowing < 30%), both aged 45 years or younger, from 38 hospitals in China between 2017 and 2020.
Background: Monitoring of lead depth is crucial to achieve left bundle branch pacing (LBBP) with a low capture threshold and avoid septal perforation, but lacks informative approach.
Objective: We aimed to prospectively assess the predictive value of current of injury on the occurrence of inadequate left bundle branch (LBB) capture threshold and acute septal perforation.
Methods: Consecutive patients who received LBBP were enrolled.