[The influence of vitamins A, E, C upon the respiration activity of the spleen lymphocytes ].

In the experiment on albino male mongrel rats some parameters of oxidative phosphorylation of spleen slices were studied after the animals were fed the antioxidant complex of vitamins E, A, and C. The stimulation of oxygen consumption rate and of tissue respiration of spleen was observed with endogenous substrates, and after exogenous substrates (succinate and glutamate) were added. After the ingestion of vegetable oil the uncoupling of oxidative phosphorylation was observed.

[Characteristics of mitochondria and myocardium ultrastructure of rats following chronic incorporation of cesium radionuclides 137 Cs].

Ultrastructure, tissue respiration and oxidative phosphorilation were studies in the myocardium of animals after chronic natural irradiation by 137Cs in quantities that can in reality threaten population of radionuclide-polluted regions. Decline in the respiratory activity of the myocardium and ultrastructural disorders can be attributed to the effects of ions of radioactive Cs which is also a potassium antagonist. A hypothesis has been put forward according to which cesium blocks potassium channels in mitochondria and thus changes the volume and configuration of internal mitochondrial membranes, and impacts the respiratory processes.

[Mitochondrial oxidation and ultrastructure of the myocardium on a background of incorporation of cesium radionuclides].

Parameters of the mitochondrial oxidation and ultrastructure of the myocardium in white rats were studied on a background of consumption of food supplemented with 137Cs at 60 or 600 Bq/kg (calculated doses were 1.5 and 15 microGy, respectively). The observed stimulation of the respiratory activity in myocardial samples cultivated on endogenous and several exogenous substrates was found to reduce the effectiveness of energy production by dissociation of oxidative phosphorylation and disruption of macroerg deposition in the form of creatine phosphate.