Investigation of the inhibitory peptide effect as novel strategy in cancer treatment: Targeting the tetramerization of lactate dehydrogenase A.

The Warburg effect is detected in numerous types of solid tumors and is characterized by the enhancement of glucose consumption and an increase in the rate of glycolysis in cancer cells. Lactate dehydrogenase A (LDHA) plays a critical role in the Warburg effect and to date, a number of LDHA inhibitors have been identified that act as competitive inhibitors of both the substrate pyruvate and the coenzyme NADH. In our previous study, a set of novel peptides were designed using in silico structure-based method with the aim of inhibiting the activity of LDHA by disrupting the interaction between its enzyme subunits.

Genetic Diversity and Population Structure of Primary Tritipyrum Lines in Comparison with Bread Wheat Varieties and Triticale Lines using SCoT Markers.

Background: Triticale and tritipyrum as a new artificial cereal were investigated as potential stress-resistant alternatives within the Triticeae tribe due to their notable adaptability to environmental stresses.

Objectives: The first purpose of this study was to determine the genetic variation of 14 genotypes on physiological traits in arid and semi-arid climate of Yazd province on primary trans chromosomal tritipyrum (PTCT) lines, promising triticale lines, and Iranian and Afghan bread wheat cultivars, and the second purpose was to investigate the genetic diversity and classification of genotypes using start codon targeted (SCoT) markers.

Materials And Methods: The photosynthesis pigments, proline, and catalase enzyme activity of 14 genotypes were determined.

INVESTIGATION THE EXPRESSION LEVELS OF MIR-181 AND HOXA11 GENE IN EUTOPIC AND ECTOPIC ENDOMETRIAL TISSUE.

Objectives: The exact pathogenesis of the endometriosis is not apparent. MicroRNAs (miRNAs/miRs) are non-coding RNAs that regulate gene expression at the post-transcriptional level. MicroRNAs can be used a diagnostic and therapeutic tools in different disorders such as endometriosis.

Impact of anti leukemia inhibitory factor antibody on immune related gene expression in breast cancer Balb/c mouse model.

Leukemia inhibitory factor (LIF) is involved in the progression of different cancers. In this study, we investigated the effect of anti-LIF antibodies on immune-related gene expression in the Balb/c mouse model of breast cancer. To immunize mice against LIF, recombinant LIF with Freund adjuvant was injected into the test group, whereas the control group received phosphate-buffered saline with adjuvant.

Protective effects of alpha-lipoic acid and alagebrium chloride against testicular dysfunction induced by varicocele and advanced glycation end (AGE) - Rich diet in a rat mode.

Heat stress from varicocele can heighten oxidative stress in the testes, impacting sperm function and male fertility. Antioxidant therapy is explored as a remedy for varicocele, while dietary factors like processed foods, sugar, and saturated fats correlate with male infertility. Advanced glycation end products (AGEs), generated through glycation processes, can provoke oxidative stress, inflammation, and adverse health consequences.