Histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment.

Infective endocarditis is an uncommon manifestation of infection with Histoplasma capsulatum. The diagnosis is frequently missed, and outcomes historically have been poor. We present 14 cases of Histoplasma endocarditis seen in the last decade at medical centers throughout the United States.

Amphotericin B tolerance: a characteristic of Candida parapsilosis not shared by other Candida species.

Thirty yeast isolates from clinical specimens were tested for their susceptibility to amphotericin B at 30 C, 37 C, and 39 C. Of the six Candida albicans, five Candida tropicalis, one Candida guilliermondii, one Candida krusei, one Candida pseudotropicalis, two Torulopsis glabrata, and four Cryptococcus neoformans isolates tested, all were inhibited at amphotericin B concentrations of less than or equal to 0.4 micrograms/ml and killed by concentrations of amphotericin B that were less than or equal to 16-fold higher than the minimal inhibitory concentration (MIC).