[Treatment of attack-like forms of schizophrenia in patients with residual cerebral organic insufficiency].

As a result of studying 727 therapy courses conducted in 90 patients with attack-like schizophrenia, who suffered 294 attacks, it has been demonstrated that in case these patients have residual organocerebral failure, a special choice of "sparing" therapy is required. The treatment of these patients consists in the use of neuroleptics which do not provoke any marked extrapyramidal side effects (sonapax, eglonyl, leponex), tranquilzers and antidepressants possessing no cholinolytic effect (pyrazidol, nuredal). If the use of powerful antipsychotic neuroleptics and tricyclic antidepressants is required, it is indicated that they can be applied in the form of intravenous infusions.

[Side effects of psychopharmacotherapy in patients with schizophrenia proceeding against a background of organic cerebral insufficiency].

Analyzed were 1999 courses of treatment in 212 patients with paroxysmal and paranoid schizophrenia. Twelve groups of side-effects were defined according to syndromal and structural principles. Compared to the uncomplicated schizophrenic patients, the ones with organic cerebral insufficiency had higher sensitivity to psychopharmacologic drug therapy.

[Enhanced sensitivity to psychotropic preparations and its relation to organic brain insufficiency].

An analysis of 1999 courses of psychopharmacotherapy (PPT) conducted in 90 patients with attack-like forms of schizophrenia and in 122 patients with the paranoid form has revealed an adverse effect of cerebro-organic insufficiency on PPT tolerance. In patients with the maximal degree of residual cerebro-organic insufficiency an elevated sensitivity to PPT occurred 2-2.2 times as often as in patients with a history of the minimal number of exogenously aggravated factors.