Publications by authors named "S M Schonfeld"
Acute myeloid leukemia (AML) often requires allogeneic hematopoietic cell transplantation (alloHCT) for cure, but historically alloHCT has been strikingly underutilized. Reasons for this remain uncertain at the population level. We examined alloHCT utilization over time and explored associations between demographic/healthcare factors and use of alloHCT by age group (AYA 15-39y, adult 40-64y, older adult 65-79y) using a linked dataset merging the Center for International Blood and Marrow Transplant Research, California Cancer Registry, and California Patient Discharge Database.
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- Childhood exposure to radioactive iodine from the Chornobyl accident increases the risk of papillary thyroid carcinoma (PTC), particularly in younger individuals.
- A study of 428 PTC cases found that cervical lymph node metastases (cLNM) were more common in PTC with certain genetic fusions compared to mutations, and this frequency varied significantly by specific gene types.
- Molecular profiling of the cLNM showed strong genetic concordance with primary PTCs and identified 17 differentially expressed genes, pointing to potential biological mechanisms in PTC metastasis that require further investigation.
Compared with the general population, hematopoietic cell transplantation (HCT) survivors are at elevated risk for developing solid subsequent neoplasms (SNs). The Center for International Blood and Marrow Transplant Research (CIBMTR) is a key resource for quantifying solid SN incidence following HCT, but the completeness of SN ascertainment is uncertain. Within a cohort of 18 450 CIBMTR patients linked to the California Cancer Registry (CCR), we evaluated the completeness of solid SN data reported to the CIBMTR from 1991 to 2018 to understand the implications of using CIBMTR data alone or combined with CCR data to quantify the burden of solid SNs after HCT.
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