Publications by authors named "S M Scharf"
Article Synopsis
- - The lymph node is structured into dynamic compartments like T and B zones, which enhance both innate and adaptive immune responses and have led to new insights across various biological and medical fields.
- - The review emphasizes advanced 3D and 4D imaging techniques to study human lymph nodes, highlighting the insights gained from these methods compared to traditional 2D tissue analysis, particularly in understanding immune interactions and lymphoma behavior.
- - Findings show that T cells move faster than B cells and reticulum cells within reactive lymphoid tissue, with variations in cell contact times potentially aiding in lymphoma classification; 4D technology can also play a key role in testing new cancer therapies.
(1) Background: Microbial keratitis is a serious eye infection that carries a significant risk of vision loss. spp. are known to cause keratitis and their bacterial endosymbionts can increase virulence and/or treatment resistance and thus significantly worsen the course of the disease.
View Article and Find Full Text PDFAssessment and Monitoring of the Wound Micro-Environment in Chronic Wounds Using Standardized Wound Swabbing for Individualized Diagnostics and Targeted Interventions.
Biomedicines
September 2024
Patient-specific diagnostic and therapeutic approaches are important in the care of people with chronic wounds. The heterogeneity of underlying disease profiles and the diversity of the wound micro-environment make generalized approaches difficult. While high-throughput molecular diagnostic methods are increasingly widespread and available, the analysis of objective biomolecular disease patterns has not found its way into everyday wound management.
View Article and Find Full Text PDFArticle Synopsis
- - Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell lymphoma, and its subtypes have varying outcomes, prompting efforts to better predict patient prognosis based on cell origin.
- - This study focused on analyzing the migration abilities of two genetic subtypes of DLBCL, MCD and EZB, using specific tests to measure their movement through microchannels and narrow spaces.
- - Results showed that EZB-type cells migrated faster and more effectively through constrictions than MCD-type cells, which had higher levels of a protein affecting nuclear stiffness, suggesting that genetic differences may impact both therapy outcomes and tumor cell motility.