[Cowpox: features of spread after cancellation of mandatory pox immunization].

Features of spread of cowpox in the contemporary conditions are examined. A decrease of population immunity to pox in the population of Russia caused by cancellation of pox immunization, hidden circulation of cowpox virus in various species of rodents, as well as lack of vigilance to pathogenic orthopoxviurses in healthcare workers were noted to create the real preconditions for the emergence of infection of humans caused by cowpox virus. Thereby presence of means of express laboratory diagnostics of cowpox and means of effective medical protection for the prevention of development of this disease in the population of Russia becomes an actual necessity.

[Monkeypox: features of spread after cancellation of mandatory pox immunization].

Features of spread of monkeypox after eradication of smallpox and cancellation of mandatory pox immunization are examined. In the condition of cancellation of mandatory pox immunization, a decrease of population immunity to pox in the population, a lack of vigilance in most of the medical specialists to diseases caused by other pathogenic for human orthopoxviruses was noted. This situation complicates the prognosis of the development of possible outbreaks of infection of humans by monkeypox.

Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent.

Background: Onconase represents a new class of RNA-damaging drugs. Mechanistically, Onconase is thought to internalize, where it degrades intracellular RNAs such as tRNA and double-stranded RNA, and thereby suppresses protein synthesis. However, there may be additional or alternative mechanism(s) of action.

Ribonucleases and immunoRNases as anticancer drugs.

Ribonucleases degrade RNA, now considered an important drug target. The parent member of this protein superfamily is bovine pancreatic RNase A that functions as a digestive enzyme. Other physiological roles and activities have been ascribed to more recently discovered members of this superfamily.

The notch target gene HES1 regulates cell cycle inhibitor expression in the developing pituitary.

The pituitary is an endocrine gland responsible for the release of hormones, which regulate growth, metabolism, and reproduction. Diseases such as hypopituitarism or pituitary adenomas are able to disrupt pituitary function leading to suboptimal function of the entire endocrine system. Growth of the pituitary during development and adulthood is a tightly regulated process.