Publications by authors named "S M Rosengren"
Purpose: Number magnitude is often represented spatially in the mind by a mental number line, on which small numbers are located to the left of space and large numbers to the right. As vestibular dysfunction can affect aspects of spatial cognition, we wondered whether patients with acute vestibular loss would show a directional bias along the mental number line.
Methods: We gave 18 patients with vestibular neuritis (VN) (eight left VN, ten right; mean age 54 years, range 31-75 years; four females) and 15 normal age- and education-matched controls (mean age 47 years, range 26-75 years; 11 females) a mental number bisection task.
Article Synopsis
- The ocular vestibular evoked myogenic potential (oVEMP) measures how well the otolith organs function, primarily focusing on muscle responses elicited by sound stimuli.
- The study examined the characteristics and pathways of late peaks in oVEMPs across different groups: healthy individuals, and patients with various levels of hearing and vestibular loss, using both bone and air-conducted stimuli.
- Findings revealed that in healthy subjects, the initial waves were largest and predominantly contralateral, while patients with vestibular function could still produce late peaks, suggesting they originate from a different mechanism unrelated to hearing status.
Article Synopsis
- Vestibular migraine (VM) is a prevalent cause of dizziness that can mimic other conditions like benign paroxysmal positional vertigo (BPPV) and Meniere's disease (MD), depending on the episode duration.
- The study compared symptoms and vestibular test results among 108 patients grouped by their conditions, including those experiencing short and medium-duration VM episodes.
- Findings indicated high symptom overlap among the groups, with no significant differences based on episode duration, suggesting that VM can resemble other disorders based on how long the dizziness lasts rather than distinct symptoms.
Analysis of Evusheld safety and efficacy in multiple sclerosis patients.
Mult Scler Relat Disord
August 2024
Background: In December 2021, the U.S. Food and Drug Administration issued emergency use authorization for the combination monoclonal antibodies tixagevimab and cilgavimab (Evusheld - AstraZeneca) for COVID-19 pre-exposure prophylaxis.
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- Patients with bronchiectasis experience worse health outcomes due to infections, often linked to weakened neutrophil antimicrobial responses that allow bacteria to persist.
- The study investigated the effectiveness of gremubamab, a bispecific monoclonal antibody, in boosting the ability of neutrophils to kill bacteria associated with bronchiectasis.
- Results showed that gremubamab significantly improved neutrophil functions, including opsonophagocytic killing and phagocytosis, without interfering with the body's natural antibodies, thus reducing the harmful effects of the bacterial infection.*