Publications by authors named "S M Rombach"
Objective: To describe clinical features, treatment strategies and visual acuity changes of eyes with uveitic macular oedema (UMO) in ocular tuberculosis (OTB) patients from a non-TB-endemic country.
Methods: This retrospective study was conducted using a 10-year period registry of OTB patients diagnosed in Erasmus MC, Rotterdam. Longitudinal analysis of visual acuity trajectory in eyes with and without UMO was performed using linear mixed effect model.
Article Synopsis
- Sarcoidosis and tuberculosis (TB) are similar granulomatous diseases that can cause uveitis, prompting a study of inflammation-related proteins in serum from patients in the Netherlands (sarcoidosis) and Indonesia (TB).
- Researchers found 192 proteins unique to sarcoidosis and 102 unique to active pulmonary TB when compared to healthy controls, but noted overlapping immune pathways in both diseases.
- A specific B-lymphocyte activation signature linked to sarcoidosis was identified, distinguishing it from TB, indicating that B-cell signaling differences are a crucial immunological factor between the two conditions.
Introduction: There is a scarcity of long-term follow-up data and management strategies for recurrent uveitis in tubercular uveitis (TBU), especially in cases extending beyond 10 years after the completion of initial antitubercular treatment (ATT).
Methods: This retrospective study involved five TBU patients who were initially treated with a combination of four-drug ATT for 6 months, and the five of them had more than 10 years of follow-up after uveitis resolution upon ATT completion. We describe the occurrence of recurrent uveitis and present our approach to managing these recurrent episodes.
Purpose: To assess the clinical relevance of pathophysiology-based biomarkers, specifically serum C1q and whole blood interferon gene signature score (IGSS), in ocular tuberculosis (OTB) diagnosis by conducting an integrative analysis of clinical presentations and treatment response.
Methods: This retrospective cohort study analysed data from 70 patients with suspected OTB at a tertiary care uveitis practice in Indonesia. Serum C1q levels and whole blood IGSS were quantified.
Clinical Features and Predictors of Treatment Outcome in Patients with Ocular Tuberculosis from the Netherlands and Indonesia: The OculaR TB in Low versus High Endemic Countries (ORTEC) Study.
Ocul Immunol Inflamm
January 2025
Article Synopsis
- The study compares ocular tuberculosis (OTB) patients in the Netherlands, a low TB-endemic country, with those in Indonesia, a high TB-endemic country, focusing on clinical features, treatment approaches, and outcomes.
- Indonesian patients exhibited more severe symptoms and complications, such as higher rates of blindness and acute uveitis, while both groups had similar overall treatment success rates.
- Key predictors of poor treatment response included the presence of severe anterior chamber cells, specific types of eye lesions, and retinal vasculitis at the start of treatment.