Publications by authors named "S M Rissanen"
Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments.
Proc Natl Acad Sci U S A
November 2024
The use of lipid nanoparticles (LNPs) for therapeutic RNA delivery has gained significant interest, particularly highlighted by recent milestones such as the approval of Onpattro and two mRNA-based SARS-CoV-2 vaccines. However, despite substantial advancements in this field, our understanding of the structure and internal organization of RNA-LNPs -and their relationship to efficacy, both in vitro and in vivo- remains limited. In this study, we present a coarse-grained molecular dynamics (MD) approach that allows for the simulations of full-size LNPs.
View Article and Find Full Text PDFThe association between self-assessed cold threshold (CT) and thermal insulation of clothing (I) was analysed in 283 poultry workers in Thailand. The mean CT was 13.5 °C (range - 28-29) and the mean I was 1.
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- The text discusses the limitations in developing new therapies due to inadequate predictive in vitro models and presents Organ-on-chip (OOC) technologies as a promising solution for improved tissue and disease modeling.
- It introduces a scalable microfluidic platform called AKITA, designed for high, medium, and low throughput applications compatible with existing laboratory workflows in a standardized format.
- AKITA is specifically optimized for studying vascularized biological barriers like the blood-brain barrier, using precise flow control and integrated sensors to monitor barrier integrity, ultimately aiding in preclinical drug testing and precision medicine.
Objective: The aim of this study was to develop a feasible method for the detection of negative myoclonus (NM) through long-term home measurements in patients with progressive myoclonus epilepsy type 1.
Methods: The number and duration of silent periods (SP) associated with NM were detected during a 48 h home recording using wearable surface electromyography (EMG) sensors.
Results: A newly developed algorithm was able to find short (50-69 ms), intermediate (70-100 ms), and long (101- 500 ms) SPs from EMG data.
Background: The importance of work engagement has been emphasised due to the increasing demand for health- and social care and the shortage of skilled labour. Improving organisational and managerial factors is important when enhancing professionals' work engagement. The association between management and work engagement has only been established in previous studies at a general level, but the association between appreciative management and work engagement has not received equivalent research interest.
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