[Role of kinins in the pathogenesis of craniocerebral injury and the validation of corrective antiproteolytic therapy].

The role of the kinin system in the development of extra- and intracerebral complications in the acute period of severe craniocerebral trauma was studied from complex clinical and biochemical examination. The authors substantiate the expediency of applying corrective antiproteolytic therapy, in which case the predominant trend of its action--inhibition of kinin production in the vascular bed or on the tissue level--must be taken into account. The time, duration, and methods of Contrykal administration were developed.

[Comparative effectiveness of epsilon-aminocaproic acid and contrical in preventing complement activation on immune complexes].

Experiments on formation of circulatory immune complexes followed by activation of the complement components were made on sensitized guinea-pigs after intravenous injection of human gamma-globulin as specific antigen. epsilon-Aminocaproic acid did not affect the formation of circulatory immune complexes but significantly inhibited complement activation. Contrykal did not alter the formation of the immune complexes but slightly inhibited activation of the complement components.

[Dynamics of components of the kallikrein-kinin system in the arterial and venous blood and cerebrospinal fluid of patients with severe cranio-cerebral injuries].

Comparative study of the activity dynamics of the components of the kallikrein-kinin system in portions of blood flowing to the brain and draining from it and in the cerebrospinal fluid was carried out in 26 patients with a severe craniocerebral trauma. It was found that activation of the system is displayed by a considerable increase in spontaneous esterase activity, a fall in the activity of kallikrein inhibitors, and a decrease in the content of prekallikrein and kininogen. The degree of activation depends on the severity of the lesion, reaches the maximum level by the 3rd--4th day of the development of the pathological process, and is manifested most fully in blood draining from the brain.