Publications by authors named "S M R Matarese"
Article Synopsis
- * In this study, human kidney cells exposed to both polyethylene microplastics and BPA showed decreased cell viability and increased pro-oxidant and pro-inflammatory responses compared to those exposed to either substance alone.
- * Additionally, the research found that exposure reduced levels of heat shock protein (HSP90) while increasing aryl hydrocarbon receptor (AHR) expression, highlighting the need for further investigation into how these pollutants interact and affect kidney health.
Article Synopsis
- Hemolytic uremic syndrome (HUS) is a serious condition that can happen after an infection or due to problems in the body's immune system, and there are two types: typical and atypical.
- This text discusses a 9-year-old boy who had a rare form of aHUS caused by specific genetic issues, which made his body produce autoantibodies that affected his kidneys and brain.
- The study found that many kids with aHUS needed kidney treatment and that early treatment with special therapy may help prevent kidney failure, even if the patient has infections like STEC.
Approach to the child and adolescent with Adrenal Insufficiency.
J Clin Endocrinol Metab
August 2024
The management of adrenal insufficiency is challenging, and the overall goals of treatment are to prevent life-threatening adrenal crises, to optimize linear growth, to control androgen levels without overdosing in subjects with congenital adrenal hyperplasia (CAH) and to improve quality of life in affected individuals. Standard glucocorticoid formulations fail to replicate the circadian rhythm of cortisol and control the adrenal androgen production driven by adrenocorticotropic hormone. In order to personalize and tailor glucocorticoid therapy and to improve patient outcomes, new pharmacological strategies have been developed that best mimic physiological cortisol secretion.
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