Host Transcriptome and Microbial Variation in Relation to Visceral Hyperalgesia.

Background: Chronic visceral hypersensitivity is associated with an overstressed pain response to noxious stimuli (hyperalgesia). Microbiota are active modulators of host biology and are implicated in the etiology of visceral hypersensitivity.

Objectives: we studied the association between the circulating mRNA transcriptome, the intensity of induced visceral pain (IVP), and variation in the oral microbiome among participants with and without baseline visceral hypersensitivity.

The Legalome: Microbiology, Omics and Criminal Justice.

Advances in neuromicrobiology and related omics technologies have reinforced the idea that unseen microbes play critical roles in human cognition and behaviour. Included in this research is evidence indicating that gut microbes, through direct and indirect pathways, can influence aggression, anger, irritability and antisocial behaviour. Moreover, gut microbes can manufacture chemicals that are known to compromise cognition.

Evaluation of a capacity-building program to enhance evidence-based practice of cognitive rehabilitation providers: a pilot study.

Introduction: Cognitive rehabilitation is a complex and challenging area of brain injury rehabilitation practice, and specialized training programs are needed to upskill practitioners to ensure effective, evidence-based interventions. We developed a cognitive rehabilitation capacity-building program (CogCap) to address this need.

Aims: The aims of this study were to pilot the CogCap program with a multidisciplinary group of cognitive rehabilitation providers; to evaluate whether it improved participants' self-ratings of knowledge, skills, and confidence in cognitive rehabilitation; and to explore their perceptions and experiences of the program.

Discordance between preclinical and clinical testing of Na V 1.7-selective inhibitors for pain.

The voltage-gated sodium channel Na V 1.7 plays an important role in pain processing according to genetic data. Those data made Na V 1.