Publications by authors named "S M Poloyac"
Background: Vaginal rings formulated to deliver two drugs simultaneously have potential as user-controlled, long-acting methods for dual prevention of HIV and pregnancy.
Methods: Two phase 1 randomized trials (MTN-030/IPM 041 and MTN-044/IPM 053/CCN019) respectively enrolled 24 and 25 healthy, HIV-negative participants to evaluate safety, pharmacokinetics, and vaginal bleeding associated with use of a vaginal ring containing 200mg dapivirine (DPV) and 320mg levonorgestrel (LNG) designed for 90-day use. MTN-030/IPM 041 compared the DPV/LNG ring to a DPV-only ring (200mg) over 14 days of use.
Objective: The objective of this review is to provide the conclusions from the American Association of Colleges of Pharmacy (AACP) Council of Deans (COD) Taskforce on Research and Scholarship.
Findings: The charges and the findings of the committee are: (1) Define the scholarship needs/opportunities to strengthen the outputs. The committee recommends that AACP update its definitions of research/scholarship to include discovery, integration, application/practice, and teaching/learning.
Article Synopsis
- - The management of critical care for patients post-cardiac arrest suffers from insufficient high-quality clinical studies, leading to vague guidelines and inconsistent treatment practices.
- - Key areas like temperature control and neurological prognosis have better research backed by clinical studies, but many critical subjects lack sufficient evidence, creating gaps in guidelines.
- - An expert panel, consisting of 24 practitioners from diverse medical fields, was convened to create consensus statements on various aspects of post-arrest management, aiming to provide guidance until more definitive studies are conducted.
Article Synopsis
- The management of patients post-cardiac arrest lacks strong clinical studies, leading to uncertainty and inconsistent treatment practices.
- While some guidelines exist for critical aspects like temperature control and neurological prognosis, many important topics remain under-researched, resulting in low-quality evidence.
- To address these gaps, an expert panel was formed to reach consensus on critical care management topics, producing statements that can help guide clinicians until higher-quality studies emerge.
Background: Worsened stroke outcomes with hypertension comorbidity are insensitive to blood pressure-lowering therapies. In an experimental stroke model with comorbid hypertension, we investigated causal roles of ang II (angiotensin II)-mediated stimulation of the brain WNK (with no lysine [K] kinases)-SPAK (STE20/SPS1-related proline/alanine-rich kinase)-NKCC1 (Na-K-Cl cotransporter) complex in worsened outcomes.
Methods: Saline- or ang II-infused C57BL/6J male mice underwent stroke induced by permanent occlusion of the distal branches of the middle cerebral artery.