Cardiac Cx43 Signaling Is Enhanced and TGF-β1/SMAD2/3 Suppressed in Response to Cold Acclimation and Modulated by Thyroid Status in Hairless SHR.

The hearts of spontaneously hypertensive rats (SHR) are prone to malignant arrhythmias, mainly due to disorders of electrical coupling protein Cx43 and the extracellular matrix. Cold acclimation may induce cardio-protection, but the underlying mechanisms remain to be elucidated. We aimed to explore whether the adaptation of 9-month-old hairless SHR to cold impacts the fundamental cardiac pro-arrhythmia factors, as well as the response to the thyroid status.

A Restorative Justice Intervention in United States Prisons: Implications of Intervention Timing, Age, and Gender on Recidivism.

Restorative justice seeks to balance the needs of the victim, offender, and community by repairing the harm caused by crime and wrongdoing and improving the prosocial competencies and accountability of the offender in response to an offense. Restorative justice interventions (RJIs) offer an alternative method to reduce harm and short- and long-term recidivism. However, empirical validation of mechanisms and moderating factors warrant additional inquiry within jail and prison settings.

The Nature and Extent of Component Analyses for Improving or Mitigating Behavior: A Systematic Review.

A component analysis is an approach where two or more independent variables are evaluated as a package and independently. The approach is used to assess and identify which component of a treatment package is the most effective. The purpose of this review is to document the application of component analyses to improve or mitigate non-academic behaviors with individuals with disabilities.

A Multidisciplinary Intubation Algorithm for Suspected COVID-19 Patients in the Emergency Department.

Introduction: Intubation of patients suspected of having coronavirus disease 2019 (COVID-19) is considered to be a high-risk procedure due to the aerosolization of viral particles. In an effort to minimize the risk of exposure and optimize patient care, we sought to develop, test, provide training, and implement a standardized algorithm for intubating these high-risk patients at our institution.

Methods: We developed an initial intubation algorithm, incorporating strategic use of equipment and incorporating emerging best practices.

Cardiac Cx43 and ECM Responses to Altered Thyroid Status Are Blunted in Spontaneously Hypertensive versus Normotensive Rats.

Heart function and its susceptibility to arrhythmias are modulated by thyroid hormones (THs) but the responsiveness of hypertensive individuals to thyroid dysfunction is elusive. We aimed to explore the effect of altered thyroid status on crucial factors affecting synchronized heart function, i.e.