Health-Related Quality of Life in Patients With Relapsed/Refractory Multiple Myeloma Treated With Carfilzomib, Dexamethasone, and Daratumumab Versus Carfilzomib and Dexamethasone: An Analysis of Patient-Reported Outcomes From the Phase 3 CANDOR Trial.

Background: In the phase 3 CANDOR trial (NCT03158688), daratumumab added to carfilzomib and dexamethasone (KdD) significantly prolonged progression-free survival relative to carfilzomib and dexamethasone (Kd) alone in previously treated patients with relapsed/refractory multiple myeloma (RRMM).

Materials And Methods: We present a post hoc analysis of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30-item module (EORTC QLQ-C30) and EORTC QLQ Myeloma 20-item module (EORTC QLQ-MY20) patient-reported outcome (PRO) measures from the CANDOR trial.

Results: Median (range) duration of observation for PROs was 18.

Promoting Gender Inclusive Language in Radiology: Next Steps?

Further advancement of the care experience for transgender and gender diverse (TGD) patients can substantially benefit from implementing expanded electronic health record (EHR) systems that capture sexual orientation and gender identity (SOGI) information, along with processes for acquiring and maintaining accuracy of these data fields. Once this is in place, it could advance existing and create new opportunities in radiology for providing sensitive care to TGD patients. Using gender sensitive language in radiology reports and during imaging appointments shows respect and demonstrates inclusivity for TGD patients.

Racial and Ethnic Disparities in Referral to Outpatient Heart Failure Management at Hospital Discharge: A Get With The Guidelines Analysis.

Background: Black and Hispanic patients with heart failure (HF) have a higher risk of adverse clinical outcomes. Currently, it is unclear whether there are disparities in referral to outpatient HF management programs based on race and ethnicity.

Methods And Results: We used the American Heart Association GWTG-HF (Get With The Guidelines-Heart Failure) registry to examine 402 225 patients hospitalized for acute HF from January 1, 2010 to December 31, 2021.

A Comprehensive, Analytical Narrative Review of Polysaccharides from the Red Seaweed : Pharmaceutical Applications and Mechanistic Insights for Human Health.

species, a widely distributed genus of red macroalgae, have gathered significant attention for their diverse medical applications attributable to their bioactive sulphated polysaccharides (SPs). This review examines the global narrative of various SP applications in terms of their therapeutic potential and mechanistic insights into the use of these SPs against a range of medical conditions, including cancer, inflammation, neurodegenerative disorders, diabetes, and immune dysfunctions. SPs extracted from and have demonstrated potent anti-tumour activities by inducing apoptosis through various mechanisms, including the upregulation of CD8 T cells and IL-2, inhibition of EGFR/MAPK/ERK signalling pathways, and activation of the Fas/FasL pathway.

Primary Intrathoracic Synovial Sarcoma: An Analysis of Outcomes of This Rare Disease.

Primary intrathoracic synovial sarcoma (SS) is a rare entity. The objective of this study was to evaluate survival outcomes for patients with intrathoracic SS presenting with localized disease at diagnosis. We conducted a retrospective review of 63 patients diagnosed with intrathoracic SS between 1997 and 2020.