Publications by authors named "S M Pagnotta"
Article Synopsis
- * The study identifies and characterizes TgREMIND and TgBAR2, two proteins with BAR domains that play key roles in the creation of essential organelles and vesicular trafficking in the parasite.
- * TgREMIND can bind to and remodel membranes, while TgBAR2 uniquely deforms anionic membranes, highlighting their differing roles in the parasite's membrane dynamics and trafficking system.
Dementia is an age-related syndrome characterized by the progressive deterioration of cognition and capacity for independent living. Diabetes is often associated with cognitive decline and shares similar pathophysiological mechanisms with dementia, such as systemic inflammation, oxidative stress, insulin resistance, and advanced glycation end-products formation. Therefore, adequate diabetes management may reduce the risk of cognitive decline, especially in patients with other comorbidities and risk factors.
View Article and Find Full Text PDFThis chapter shows applying the Asymmetric Within-Sample Transformation to single-cell RNA-Seq data matched with a previous dropout imputation. The asymmetric transformation is a special winsorization that flattens low-expressed intensities and preserves highly expressed gene levels. Before a standard hierarchical clustering algorithm, an intermediate step removes noninformative genes according to a threshold applied to a per-gene entropy estimate.
View Article and Find Full Text PDFArticle Synopsis
- Brain insulin resistance connects energy metabolism failure to cognitive decline in type 2 diabetes and Alzheimer's disease, but the early changes leading to insulin resistance are not well understood.
- Abnormal levels of biliverdin reductase-A (BVR-A) are found in both conditions, linked to insulin resistance and affecting insulin signaling and energy production in the brain.
- The study reveals that lower BVR-A disrupts insulin response and mitochondrial function, highlighting its importance for potential therapeutic targets to combat brain insulin resistance and neurodegeneration.