Publications by authors named "S M O C Marinho"
Aryl Hydrocarbon Receptor (AHR) ligands, upon binding, induce distinct gene expression profiles orchestrated by the AHR, leading to a spectrum of pro- or anti-inflammatory effects. In this study, we designed, synthesized and evaluated three indole-containing potential AHR ligands (FluoAHRL: AGT-4, AGT-5 and AGT-6). All synthesized compounds were shown to emit fluorescence in the near-infrared.
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- SARS-CoV-2 infection can cause various neurological issues during both the acute and Long COVID phases, affecting cognition, sleep, smell, and mental health.
- These symptoms are more frequently reported in young adults and women, and they can occur after both severe and mild cases of COVID-19.
- The prevalence of neurological symptoms in Long COVID raises concerns due to significant health impacts and associated costs, estimated at around 3.7 trillion US dollars.
Article Synopsis
- A recent study explored the relationship between ε4 gene polymorphism, cognitive deficits, and COVID-19 in outpatient patients experiencing neurological symptoms for over three months post-infection.
- The research included 219 confirmed COVID-19 patients, finding that a significant portion reported memory issues, though only a small percentage had these concerns verified through cognitive screening tests.
- Results indicated a higher prevalence of the ε4 allele in patients with cognitive decline compared to those without, and the association remained strong even after considering sleep disorders and anxiety symptoms.
A nephrogenic mechanism underlies dexmedetomidine-induced polyuria. A case report.
Rev Esp Anestesiol Reanim (Engl Ed)
April 2024
Dexmedetomidine's α-adrenoreceptor agonism has been gaining popularity in the anesthetic room as a sedative-hypnotic and analgesic agent, and with extensive perioperative use rising concern about side effects is necessary. Bradycardia and hypotension are common adverse effects, but there are also several reports of excessive urine output, possibly due to vasopressin secretion and permeability of collecting ducts. Polyuria usually resolves with discontinuation of the drug, and significant morbidity has not been reported.
View Article and Find Full Text PDFTransfer RNA fragments (tRFs) have gene silencing effects similarly to miRNAs, can be sorted into extracellular vesicles (EVs) and are emerging as potential circulating biomarkers for cancer diagnoses. We aimed at analyzing the expression of tRFs in gastric cancer (GC) and understanding their potential as biomarkers. We explored miRNA datasets from gastric tumors and normal adjacent tissues (NATs) from TCGA repository, as well as proprietary 3D-cultured GC cell lines and corresponding EVs, in order to identify differentially represented tRFs using MINTmap and R/Bioconductor packages.
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