Publications by authors named "S M Nkadimeng"
Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the methanol leaf extract of L.
View Article and Find Full Text PDFLeaf extract of ameliorates biomarkers of neuroinflammation, memory loss, and neurobehavioral deficit in N(ω)-nitro-L-arginine methyl ester (L-NAME) treated rats.
Biomarkers
May 2023
Purpose: commonly known as Cashew is a plant that is widely used in African traditional medicine. It is endowed with phytochemical constituents that are responsible for its medicinal properties.
Methods: Twenty-five male Wistar rats were grouped as follows: Control (Group A), Group B (L-NAME 40 mg/kg), Group C (100 mg/kg extract plus 40 mg/kg L-NAME), Group D (200 mg/kg extract plus 40 mg/kg L-NAME) and Group E (10 mg/kg of Lisinopril plus 40 mg/kg L-NAME).
Naringin abrogates angiotensin-converting enzyme (ACE) activity and podocin signalling pathway in cobalt chloride-induced nephrotoxicity and hypertension.
Biomarkers
March 2023
Article Synopsis
- The study investigates the protective effects of Naringin (NAR), a natural antioxidant, against kidney and heart issues caused by cobalt chloride (CoCl) in male rats.
- Rats were divided into different groups to assess the impact of CoCl and varying doses of NAR over seven days on renal damage and blood pressure levels.
- Results showed that CoCl led to hypertension and kidney damage, while NAR treatment reduced these effects, possibly by interfering with specific signaling pathways related to kidney function.
Article Synopsis
- Fifteen rhenium(I) tricarbonyl complexes were created using a mixed ligand approach, achieving an average yield of 84%.
- The complexes were characterized with various spectroscopy techniques, revealing a trend in carbonyl stretching frequencies affected by the presence of fluorine atoms in the ligand.
- Biological tests showed one complex, fac-[Re(Pico)(CO)(HO)], to be toxic, providing useful data for potential drug toxicity controls.
L-arginine and lisinopril supplementation protects against sodium fluoride-induced nephrotoxicity and hypertension by suppressing mineralocorticoid receptor and angiotensin-converting enzyme 3 activity.
Environ Sci Pollut Res Int
February 2023
Sodium fluoride (NaF) is one of the neglected environmental toxicants that has continued to silently cause toxicity to both humans and animals. NaF is universally present in water, soil, and atmosphere. The persistent and alarming rate of increase in cardiovascular and renal diseases caused by chemicals such as NaF in mammalian tissues has led to the use of various drugs for the treatment of these diseases.
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