Publications by authors named "S M Mourad"
Nanoparticle innovations in targeted cancer therapy: advancements in antibody-drug conjugates.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Antibody-drug conjugates (ADCs) have emerged as a promising strategy in targeted cancer therapy, enabling the precise delivery of cytotoxic agents to tumor sites while minimizing systemic toxicity. However, traditional ADCs face significant limitations, including restricted drug loading capacity, where an optimal drug-to-antibody ratio (DAR) is crucial; low DARs may lead to insufficient potency, while high DARs can cause rapid clearance and increased toxicity. Additionally, ADCs often suffer from instability in circulation due to the potential for premature release of cytotoxic agents, resulting in off-target effects and reduced therapeutic efficacy.
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- Children with Down syndrome (DS) have a higher prevalence of overweight and obesity compared to their typically developing peers, and this study focuses on a specific gene polymorphism (FTO rs17817449) that may be linked to this issue.
- The research included 100 DS children categorized by their BMI, revealing that those who were overweight or obese had a significantly higher frequency of the FTO rs17817449 T allele and certain genotypes compared to non-obese DS children.
- The findings suggest a clear association between the FTO rs17817449 genetic variant and obesity in DS, identifying specific genotypes and triglyceride levels as independent risk factors for overweight/obesity in this population.
Population-Based Survey of Urinary Incontinence, Overactive Bladder, and Other Lower Urinary Tract Symptoms in Five Developing Countries: Results of the BEBIC Study.
Neurourol Urodyn
November 2024
Article Synopsis
- * A cross-sectional survey conducted from August 2019 to April 2021 involved 1,477 adults over 18, with findings showing 37.1% experienced UI weekly, highlighting variations in UI types among countries—Cameron reported the highest at 40%, while Brazil had the lowest at 15%.
- * Common symptoms identified included urinary urgency (59.9%) and nocturia (50.6%), with men reporting voiding issues more often, while women experienced
The development of two eco-friendly analytical methods for the simultaneous determination of eight cardiovascular drugs; hydrochlorothiazide (HCT), captopril (CPL), lisinopril (LSP), valsartan (VAL), atorvastatin (ATR), bisoprolol (BSL), amlodipine (AML) and carvedilol (CVL); alongside with the nutraceutical vincamine (VIC) is essential for sustainable pharmaceutical analysis. This study explores the application of Micellar Electro Kinetic Chromatography (MEKC) and High-Performance Liquid Chromatography (HPLC) for this purpose. In MEKC method, the separation was done using fused silica capillary (41.
View Article and Find Full Text PDFBACKGROUND Adult-onset Still's disease (AOSD) is a rare multisystem inflammatory disorder with a highly variable clinical presentation. Pulmonary complications of AOSD most commonly include pleural effusion and transient pulmonary infiltrates. In extremely rare cases, pulmonary arterial hypertension (PAH) develops as a complication.
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