Engineered extracellular vesicles expressing ICAM-1: A promising targeted delivery system for T cell modifications.

Background: Extracellular vesicles (EVs) are natural nano-carriers that possess the required crucial features of an ideal biomolecular delivery system. However, using unmodified EVs may have some limitations such as low accumulation in target sites. Studies have established that engineering EVs against different cell surface markers can overcome most of these hurdles.

Resting heart rate and the risk of incident type 2 diabetes mellitus among non-diabetic and prediabetic Iranian adults: Tehran lipid and glucose study.

Background: Resting heart rate (RHR) has been found to be a potential risk factor for developing type 2 diabetes mellitus (T2DM), with a highly significant heterogeneity among previous studies. Therefore, we examined the association of RHR and risk of incident T2DM among non-diabetic and prediabetic adults.

Methods: The study population included 2431 men and 2910 women aged ≥ 20 years without T2DM at baseline (2001-2005).

Micro and Macroscopic Stress-Strain Relations in Disordered Tessellated Networks.

We demonstrate that for a rigid and incompressible network in mechanical equilibrium, the microscopic stress and strain follows a simple relation, σ=pE, where σ is the deviatoric stress, E is a mean-field strain tensor, and p is the hydrostatic pressure. This relationship arises as the natural consequence of energy minimization or equivalently, mechanical equilibration. The result suggests not only that the microscopic stress and strain are aligned in the principal directions, but also microscopic deformations are predominantly affine.

Fluorescence labeling of anchor-modified Mart-1 peptide for increasing its affinity for HLA-A*0201: Hit two targets with one arrow.

One of the most successful strategies in designing peptide-based cancer vaccines is modifying natural epitope peptides to increase their binding strength to human leukocyte antigens (HLAs). Anchor-modified Mart-1 peptide (ELAGIGILTV) is among the artificial epitope peptides with the highest binding affinity for HLA-A*0201. In this study, by fluorescence labeling of its either C- or N-terminus with N -(5-carboxyfluorescein)-l-lysine, we not only made it traceable but also drastically increased its binding strength to HLA-A*0201.

Association between Wrist Circumference and Risk of Any Fracture in Adults: Findings from 15 Years of Follow-Up in the Tehran Lipid and Glucose Study.

We evaluated whether wrist circumference (WrC), as a novel anthropometric measure, is associated with incidences of any fractures. The study population included 8288 adults (45.3% men) aged ≥30 years, who were followed for incidences of any fractures from 31 January 1999 to 16 March 2016.