An Integrative Migraine Polygenic Risk Score Is Associated with Age at Onset But Not Chronification.

: Genome-wide association studies (GWASs) demonstrate a complex genetic landscape for migraine risk. Migraine polygenic risk scores (PRSs) developed from GWAS data may have utility for predicting disease course. We analyzed the strength of association between an integrative migraine PRS and age at onset and chronification.

IVF with frozen-thawed sperm after prolonged capacitation yields comparable results to ICSI in horses: A morphokinetics study.

Intracytoplasmic sperm injection (ICSI) is the current clinical practice for the in vitro production of equine embryos. The use of conventional fertilization methods such as in vitro fertilization (IVF), has historically been associated with poor success in horses. However, recent improvements have led to better outcomes with IVF, though only when using fresh semen, which limits its use in clinical practice.

A 650-Myr history of Earth's axial precession frequency and the evolution of the Earth-Moon system derived from cyclostratigraphy.

The preservation of Milankovitch cycles in the stratigraphic record provides independent geological information to study our ancient solar system and can be leveraged to constrain existing theoretical models. Here, we identify 34 high-quality cyclostratigraphic records spanning the past 650 million years and use them to infer the evolution of the Earth-Moon system through a Bayesian inversion method. We reconstruct the time evolution of Earth's axial precession frequency, lunar distance, length of day, and the periods of obliquity and climatic precession cycles.

The existence of manual mode increases human blame for AI mistakes.

People are offloading many tasks to artificial intelligence (AI)-including driving, investing decisions, and medical choices-but it is human nature to want to maintain ultimate control. So even when using autonomous machines, people want a "manual mode", an option that shifts control back to themselves. Unfortunately, the mere existence of manual mode leads to more human blame when AI makes mistakes.

Unlocking the Complexity: Exploration of Acute Lymphoblastic Leukemia at the Single Cell Level.

Acute lymphoblastic leukemia (ALL) is the most common cancer in children. ALL originates from precursor lymphocytes that acquire multiple genomic changes over time, including chromosomal rearrangements and point mutations. While a large variety of genomic defects was identified and characterized in ALL over the past 30 years, it was only in recent years that the clonal heterogeneity was recognized.